Increased urobilinogen

Introduction Urobilinogen is derived from the binding of bilirubin. In combination with bilirubin in the lower part of the small intestine and in the colon, it is decoupled by the action of intestinal bacteria. After several stages of reduction, bilirubin becomes urinary biliary and then excreted with feces. A part of urinary biliary is absorbed into the portal vein from the intestine, most of which is taken up by the liver cells and then discharged into the intestinal fluid (intestinal hepatic circulation), and part of it enters the systemic circulation from the portal vein and is excreted from the urine through the kidney. A variety of factors can cause an increase in urinary biliary.

Cause

Reasons for high urinary bile:

1. When suffering from hemolytic jaundice or other hemolytic diseases, the bilirubin excretion increases. In the intestinal tract, bilirubin is converted into urobilinogen by bacterial action, and excessive urobilinogen is reabsorbed by the intestinal mucosa and returned to the liver. The liver cannot convert all of it into bilirubin or the liver is damaged at the same time. Excessive urinary biliary is excreted through the kidneys, so the urinary urinary tract increases.

2, fever, heart failure, constipation, etc. can also make the urinary biliary original increase.

an examination

Related inspection

Urine routine blood routine urinary bile examination urinary triad examination

Normal urinary biliary value: urinary biliary originality is negative for urobilinogen or positive for urobilinogen. Quantification: (male) 0.3--3.55 micromoles per liter. (female) 0--2.64 micromoles per liter. (Children) 0.13--2.3 micromoles per liter.

Clinically, the urinary biliary test is one of the important methods to identify the type of jaundice: in obstructive jaundice, urinary urinary biliary tract can disappear, and urinary biliary original test is negative, such as urinary biliary tract without urine for more than seven days. May be due to complete obstruction of the biliary tract. Obstructive jaundice caused by cholelithiasis is an intermittent disappearance or reduction of urobilinogen. Hemolytic jaundice and hepatic jaundice, both positive for urobilin test.

In patients with acute hepatitis, sometimes other tests are normal, the urinary urinary bilirubin content increases, and the urobilinogen test is positive. Liver damage caused by cirrhosis and poisoning, and urinary bile test also positive.

Differential diagnosis

Differential diagnosis of increased urobilinogen:

Increased urinary tract excretion: increased urinary biliary excretion is a symptom of shunting hyperbilirubinemia syndrome. The shunt hyperbilirubinemia syndrome is Israel syndrome. Excessive bilirubin produced by bone marrow red blood cells or precursors, or directly caused by destruction and production of erythroline or tetrapyrrole precursors.

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