Capillary leak syndrome

Introduction Capillary leak syndrome is a sudden, reversible capillary permeability that rapidly penetrates blood vessels from the blood vessels into the interstitial space. Rapid onset of progressive systemic edema, hypoproteinemia, decreased blood pressure and central venous pressure, weight gain, blood concentration, severe organ failure in severe cases, common in severe trauma, sepsis, cardiopulmonary bypass After (especially after infants with cardiopulmonary bypass) and reperfusion injury, snake bites, acute lung injury or acute respiratory distress syndrome (ARDS), burns, etc.

Cause

There are many causes of CLS, which are common in severe trauma, sepsis, after cardiopulmonary bypass (especially after cardiopulmonary bypass in infants) and reperfusion injury, snake bite, acute lung injury or acute respiratory distress syndrome ( ARDS), burns, are also the pathways for the toxic effects of many drugs such as recombinant interleukin-2 and docetaxel.

an examination

Related inspection

Von Willebrand Factor Antigen (vWF:, Ag) Capillary Resistance Test Vascular Wall Detection Angiographic Vascular Color Doppler

Systemic edema, hypoproteinemia, blood pressure and central venous pressure are reduced, weight gain, blood concentration, multiple organ failure can occur in severe cases, when there is suspicion, it is necessary to actively check blood pressure, blood routine, urine routine , liver and kidney function, B-ultrasound, blood electrolyte examination, blood gas analysis, blood stasis, fasting blood sugar, etc. to clear the situation.

Differential diagnosis

CLS should be distinguished from the systematic systemic Capillary Leak Syndrome (SCLS) reported in the literature. SCLS was first reported by Clarkson et al in 1960. It can be recurrent without inducement and is a rare group of unexplained low causes. Volumetric hypotension, blood concentration, non-proteinuria hypoproteinemia, systemic edema, and clinical syndrome with atypical globulinemia in most cases. In severe cases, heart, lung, kidney and other important organ failures may occur, and may progress to multiple myeloma, which has a high mortality rate. SCLS is also caused by increased capillary permeability, but the specific pathogenesis is unclear. Terbutaline (beta 2 receptor agonist) and theophylline can improve symptoms and prevent their onset.

Systemic edema, hypoproteinemia, blood pressure and central venous pressure are reduced, weight gain, blood concentration, and multiple organ failure can occur in severe cases.

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