Mouth, eye, genital damage

Introduction Mouth, eye, and genital damage are seen in Behcet Syndrome. Behcet's syndrome is a vasculitic disease. The initial description of this syndrome mainly refers to the triad of recurrent oral ulcers, genital ulcers and ocular uveitis. Later I realized that it is a systemic disease. Can involve multiple systems and multiple organs. A typical or diagnostic criteria may be referred to as Behcet's disease. However, many patients are atypical or not meeting the diagnostic criteria, especially some diseases such as ulcerative ulcer, granulomatous enteritis, and segmental ileitis.

Cause

The cause is still unclear. American scholars believe that it is related to herpes simplex virus infection; Japanese scholars believe that it is related to streptococcal infection; Chinese scholars believe that it may be closely related to tuberculosis; it is also considered to be an autoimmune disease.

The disease is a vasculitis lesion. Lymphocytes and monocytes infiltrate in the blood vessel wall and around the blood vessels as well as in nearby tissues. There may be necrosis of blood vessel walls and vascular embolization. The affected blood vessels may be arteries or veins, and may be capillaries, small blood vessels (such as subcutaneous nodules), or large and medium blood vessels such as renal artery, pulmonary artery, aorta, lower extremity arteriovenous, pulmonary vein, inferior vena cava, etc. . Destruction of epithelial cells can form ulcers in the mouth and genitals, and even form ulcers of the gastrointestinal tract, and massive bleeding of the digestive tract.

an examination

Related inspection

Urethral examination for oral X-ray examination

There is no specific serological and pathological diagnosis method, mainly for clinical diagnosis. A diagnosis can be made by having a mouth, eye, genital damage (triad) or skin damage (quadruple). Positive acupuncture skin allergy test is helpful for diagnosis. For incomplete or atypical, comprehensive analysis should be combined with system performance.

Differential diagnosis

Differential diagnosis of mouth, eye, and genital damage:

1, acute female vaginal ulcer: for acute painful ulcers that occur in female yin, unmarried women are more common, ulcers are manifested in three types: gangrene, sexually transmitted diseases, miliary. The gangrenous type often has high-heat and other systemic symptoms, sexually transmitted diseases and miliary types, and no systemic symptoms. The subjective symptoms of ulcers are burning and pain, which may be associated with erythema of the lower extremities and oral ulcers. Therefore, some people think that it is the female genital manifestation of self-suppression. The course of the disease is usually several weeks and often recurs. The disease has no history of sexual intercourse, ulcer pain, soft and repeated attacks can be distinguished from sexually transmitted diseases such as hard chancre and soft chancre.

2, genital herpes: male herpes occurs in the penis, glans, coronary sulcus and other parts, rarely involving the scrotum. Women are common in the labia, clitoris, perianal and vagina and even the cervix. Often there is a burning sensation, and clusters of small leeches occur quickly. After several days, they rupture and smash, forming shallow ulcers and the base is soft. Short course of disease, easy to relapse, pregnant women with genital herpes can easily lead to miscarriage, premature birth, can also infect newborns. The disease forms a sore after the herpes, soft, short course and other characteristics can be distinguished from Behcet's disease, hard chancre, acute female yin ulcer.

3, soft squat: this disease is one of sexually transmitted diseases, caused by Haemophilus ducrei, multiple painful soft ulcers in the genitals, round or oval, irregular edges can be jagged, uneven base, surface Light yellow purulent secretion, easy to bleed.

4, hard squat: characterized by a single genital or a few painless hard ulcers, no purulent, clear and tidy borders, nearby lymph nodes. Healed in 2-3 weeks. Generally occur in male glans, coronary sulcus, penis, female size labia, vagina, etc., lips, tongue, anus, fingers are also good hair.

There is no specific serological and pathological diagnosis method, mainly for clinical diagnosis. A diagnosis can be made by having a mouth, eye, genital damage (triad) or skin damage (quadruple). Positive acupuncture skin allergy test is helpful for diagnosis. For incomplete or atypical, comprehensive analysis should be combined with system performance. For the diagnosis of Behcet syndrome, refer to the Japanese Ministry of Health and Welfare standards (see attached) and international classification standards.

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