Glucocorticoid dependence

Introduction Glycohormone dependence is a hallmark of hormone-dependent dermatitis. Relying on topical glucocorticoids, the original disease relapses or worsens after 2 to 10 days of stopping the hormone. When the hormone is re-used, the above symptoms and signs quickly subside, and the drug is stopped again, re-emerging quickly, and more severe than before, forcing the patient to use hormones for a long time. Many people lack understanding of the scope of hormone application and adverse reactions and long-term abuse, leading to adverse consequences.

Cause

(1) Indications for selection: Corticosteroids have anti-allergic effects that suppress immune response. After external use, they can alleviate congestion and edema, and the degree of itching and the inflammatory reaction of certain skin lesions are temporarily alleviated and subsided. People are often This illusion is mixed, coupled with the misinformation of advertising, many people have a lack of understanding of the scope of hormone application and adverse reactions and long-term abuse, leading to adverse consequences.

(2) Improper selection of drug varieties: corticosteroids potent preparations are most likely to cause side effects such as skin atrophy, but these drugs are abused due to the randomness of users. Experiments have shown that in the seven types of drugs, such as Pi Kang Wang cream, dermatitis cream, skin relaxing cream, freckle cream, beclomethasone cream, compound Kangnaile cream, and skin cream, the daily per capita consumption is calculated. The average amount of frost per person is the same, but the proportion of side effects is as high as 60.4%. One of the reasons is that the drug contains the most potent preparation, clobetasol, and this feature is not known to the user.

(C) too long medication time: short-term topical corticosteroids can cause epidermal atrophy and inhibit the synthesis of dermal collagen, long-term large-scale external use can cause system side effects. Experiments have shown that long-term use of drugs leads to weakened skin barrier function, increased absorption of drugs, formation of a vicious circle, and eventually worsened the condition, such as a male seborrheic dermatitis, the rotation of a variety of corticosteroids rubbing, for 14 consecutive years In addition to facial diversity lesions and Cushing's syndrome, drug-induced diabetes occurs. A female melasma patient was rubbed daily with Pi Kang Wang for 3 consecutive years. Not only did facial skin appear side effects, but drug-induced Cushing syndrome occurred. It can be seen that even if the corticosteroid is rubbed outside a small area, if it takes too long, it can also cause systemic side effects.

(4) The confusion of the beauty market and the abuse of beauty cosmetics: In the past ten years, with the rapid development of the beauty industry and the fierce competition of beauty salons, some beauty salons have incorporated hormones into skin rejuvenation and whitening cosmetics in order to attract consumers. China and Mongolia lie to consumers, so that many consumers who are eager for beauty and skin care will become dependent on long-term application of their so-called "special effect skin rejuvenation, whitening cosmetics", leading to hormone-dependent dermatitis.

an examination

Related inspection

Six sex hormone tests

1, have used hormone cream or hormone-containing skin care products. In particular, some "quick-effect freckle", "fast-acting whitening", "anti-allergic", "desensitization" products, the hormone content is larger than the ordinary hormone ointment, has become the leading cause of hormone-dependent dermatitis.

2. Dependence on hormonal ointments or hormone-containing skin care products. The disease site must often use hormone ointment or hormone-containing skin care products to relieve symptoms, just like "addictive", there will be a rebound phenomenon.

3, repeated dermatitis and eczema-like changes in the affected area, such as local redness, rash, dry peeling, etc., even thinning of the stratum corneum, secondary red blood, dark spots and so on.

Differential diagnosis

According to the long-term topical hormone or hormone-containing cosmetics, the history and unique skin lesions can be diagnosed. However, it needs to be differentiated from facial paralysis, hemorrhoids, rosacea, seborrheic dermatitis, frostbite-like lupus, and facial disseminated miliary lupus.

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