Twitching

Introduction Muscle fiber twitch is a continuous, slow spontaneous movement of muscle fibers that undulates along the longitudinal axis of the muscle. The muscle map is expressed as a single potential repeat, or a high frequency of potential continuity. Can be seen in neuromuscular rigidity, hyperthyroidism and other myopathy. Neuromuscular rigidity refers to a spontaneous, continuous, and muscle-active disease caused by peripheral neuropathy, and is a rare chronic, progressive, neuromuscular disease. Common in adolescents, both men and women can be ill, and some patients have a family history.

Cause

The cause of neuromuscular rigidity can be divided into congenital and acquired, and the latter is more common. Congenital neuromuscular rigidity is associated with voltage-gated potassium channel abnormalities encoded by the KCNA1 gene. Acquired neuromuscular rigidity is associated with the production of Anti-VGKCb autoantibodies against autonomic neuromuscular junctions, which also affects the normal function of potassium channels. There is a report of this disease with clear cell carcinoma of the right renal pelvis with cystic changes in the country. In addition, some patients have thymoma, bronchial cancer and nasopharyngeal carcinoma. Therefore, this disease may have a certain relationship with paraneoplastic syndrome and autoimmune disorders.

an examination

Related inspection

EMG motor function test

Serum muscle enzyme tests and serum electrolyte tests are helpful in differential diagnosis. The electromyogram shows a double wave, a triple wave or a multiple wave of the beam shake potential. Muscle and sural nerve biopsy showed normality in most patients. In some patients, muscle biopsy showed uneven muscle fiber size, angular fiber and muscle fiber hypertrophy, small group of muscle fibers atrophy, increased muscle nucleus, ATPase staining showed type I muscle fiber homotypic muscle grouping and type II muscle fiber atrophy, sural nerve biopsy showed secondary Demyelination and axonal degeneration, muscle pathology is neurogenic damage.

Differential diagnosis

Identify with other involuntary movements. Such as fasciculation, convulsions, convulsions, myoclonus, tremors, dance samples. The cause is limb sensation, dyskinesia, EMG suggests peripheral neurogenic damage, muscle biopsy shows muscle fiber hypertrophy, neurogenic changes, so the diagnosis of multiple peripheral neuropathy is certain.

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