Increased mitoses

Introduction Cell division is the basis of cell metabolism and reproduction. It is based on the division of the nucleus. Cell division is divided into two types: amitosis and mitosis. Generally speaking, mitosis refers to mitosis, that is, the filament of the cell is centered on the centrosome, and the chromosome formed by aggregation of chromatin is divided into two, and the cell is further divided. For the second, complete the cell division cycle. In malignant cells, during the process of cell division, chromosomes can be divided into multipolar, such as 3-pole, 4-pole, 5-pole or even more irregular forms, so that a tumor cell can be divided into three when splitting. 4, 5 or more cells, so malignant tumors grow faster.

Cause

Increased mitotic figures are hallmarks of leiomyosarcoma. Women's pregnancy, oral contraceptives, elevated estrogen levels, etc., have caused cell richness, increased mitotic figures, and changes in bleeding and necrosis.

an examination

Related inspection

Deoxyribonucleic acid staining for ribonucleic acid staining

Nuclear fission is based on the normal and pathological mitotic figures of the nucleus and filamentous division. The heterotypic refers to the characteristics of the nucleus, which is characterized by large nuclei, different sizes, dense staining, coarse chromatin, thick nuclear membrane, and nuclear shape. Regulations, nucleoli, clear, etc. The number of mitotic figures observed by paraffin section is the main basis for diagnosis. 1 The number of mitotic figures in each high-power field is more than 2, which is malignant; 2 more than 5 mitotic figures per 10 high-power fields are sarcomas; 3 every 25 The mitotic image in the high-power field is 1~5 for low-grade malignancy, more than 5 for sarcoma; 4 with atypical mitotic figures, nuclear pleomorphism and staining depth are the basic features of sarcoma; 5 every 25 The number of mitotic figures in the high power microscope is 4, and more than 20% of the round nucleus is sarcoma.

Differential diagnosis

The mitotic figures exhibited by cell division can be divided into the following types:

[1] Normal mitotic image: normal mitotic image, can be seen in normal cells of metabolism, cells repaired after cell damage, inflammatory hyperplastic cells, also seen in neoplastic cells, the number of malignant increases.

[2] pathological schizophrenia: only seen in malignant tumor cells, the chromosomes can be divided into multipolar, such as 3-pole, 4-pole, 5-pole or even more irregular forms during cell division, thus making a tumor cell When divided, it can be divided into 3, 4, 5 or more cells, so malignant tumors grow faster.

[3] Abnormal division: such as abortion, frustration, splitting, that is, the chromosome is asymmetrically split when it is divided into two, or disordered, it is difficult to complete the cell division cycle and abortion.

Nuclear fission is based on the normal and pathological mitotic figures of the nucleus and filamentous division. The heterotypic refers to the characteristics of the nucleus, which is characterized by large nuclei, different sizes, dense staining, coarse chromatin, thick nuclear membrane, and nuclear shape. Regulations, nucleoli, clear, etc. The number of mitotic figures observed by paraffin section is the main basis for diagnosis. 1 The number of mitotic figures in each high-power field is more than 2, which is malignant; 2 more than 5 mitotic figures per 10 high-power fields are sarcomas; 3 every 25 The mitotic image in the high-power field is 1~5 for low-grade malignancy, more than 5 for sarcoma; 4 with atypical mitotic figures, nuclear pleomorphism and staining depth are the basic features of sarcoma; 5 every 25 The number of mitotic figures in the high power microscope is 4, and more than 20% of the round nucleus is sarcoma.

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