Hyperlipidemia Vascular Damage

Introduction Hyperlipidemia: In general, epithelial cells on the surface of human blood vessels have protective effects on blood vessels, and blood lipids only flow in blood vessels. However, when epithelial cells are destroyed, blood lipids will break through the barrier and invade the blood vessel wall. The reasons for this are the following common factors: 1. Smoking. Harmful substances in cigarettes gradually damage the epithelial cells of blood vessels and increase the gap between epithelial cells. As the blood flows through the blood vessels, the fat is deposited in the walls of the blood vessels through the gaps in the epithelial cells. 2. High blood pressure. Excessive blood pressure causes degeneration and dysfunction of vascular epithelial cells, allowing blood lipids to enter the vessel wall.

Cause

First place: smoking. Harmful substances in cigarettes gradually damage the epithelial cells of blood vessels and increase the gap between epithelial cells. As the blood flows through the blood vessels, the fat is deposited in the walls of the blood vessels through the gaps in the epithelial cells.

Second place: high blood pressure. Excessive blood pressure causes degeneration and dysfunction of vascular epithelial cells, allowing blood lipids to enter the vessel wall.

Third place: high density lipoprotein, cholesterol (HDL-C) content is too low. High-density lipoprotein cholesterol can move freely inside and outside the vessel wall, so it can re-expose the lipids that have been deposited in the vessel wall, "reversing the process of deposition of blood lipids in the vessel wall." Smoking and lack of exercise will reduce their content.

Fourth place: Family history of early onset coronary heart disease. In male relatives, the incidence of men is earlier than 55 years, and women are older than 65 years old. They may have genetic defects and poor function of the inner wall of blood vessels.

Fifth place: Diabetes. The harm of diabetes to the blood vessel wall epithelial cells is similar to that of coronary heart disease, and it is also easy to cause atherosclerosis.

Sixth place: age. The function of vascular epithelial cells will also degenerate with age. When men are over 45 years old and women are over 55 years old, it is necessary to pay attention to active prevention and treatment.

an examination

Related inspection

Lipoprotein electrophoresis serum apolipoprotein determination of high density lipoprotein cholesterol serum apolipoprotein CII determination of serum total lipid

Human blood vessels have dialysis function, water, salt and glucose will appear in the urine, but larger substances such as albumin will not normally enter the urine through the blood vessel wall. Therefore, the appearance of albumin in the urine means that the human blood vessel wall may be damaged to some extent.

Laboratory tests: blood lipids, high-density lipoprotein, blood routine, urine routine, urine protein, etc.

Differential diagnosis

Identification of the disease: should be differentiated from systemic vascular damage.

Human blood vessels have dialysis function, water, salt and glucose will appear in the urine, but larger substances such as albumin will not normally enter the urine through the blood vessel wall. Therefore, the appearance of albumin in the urine means that the human blood vessel wall may be damaged to some extent.

The material in this site is intended to be of general informational use and is not intended to constitute medical advice, probable diagnosis, or recommended treatments.