Nerve sheath myxoma

Introduction to nerve sheath myxoma Nerves heathmyxoma (neurothekeoma) is a spectrum disease of neurogenic stromal tumors characterized by the proliferation of sphincter cells in varying degrees of myxomatous stroma. basic knowledge The proportion of illness: 0.004% Susceptible people: no special people Mode of infection: non-infectious Complications: Mildew

The cause of sphincter myxoma

(1) Causes of the disease

The cause is still unknown.

(two) pathogenesis

The pathogenesis is still unclear.

Nerve sheath mucinoma prevention

Surgical resection, incomplete resection can relapse.

Nervous sheath myxoma complications Complications

The most common complication after surgery is Horner syndrome.

Symptoms of myxonal myxoma common symptoms nodular papules

Can be divided into classic and cell type, classic type of neuromyeloma, occurs in middle-aged people (mean age 48 years) mainly occurs in the head and upper limbs, a single lesion is skin color or pink, soft to rubber hardness The papules and nodules, cell-type nerve sheath myxoma occurs in young people (mean age 24 years), more common in women, occurs in the head, neck, skin lesions are firm, pink or reddish brown pimples and nodules The size is below 3cm. The typical nerve sheath myxoma often has no symptoms, occasionally tenderness, and the lesion is benign, but it can recur if the resection is incomplete.

Examination of nerve sheath myxoma

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Histopathology: Classical neuromyeloma usually consists of interconnected lobules and bundles that form a clear medullary tumor. The bundle contains a large number of myxomatous stroma, with only a small number of cellular components, different cell morphology, obese fusiform, slender Shape, bipolar cytoplasmic process, or star-shaped, nuclear staining slightly deep, no obvious nucleoli, mitotic figures are rare or absent, occasionally multinucleated giant cells, mucinous matrix often compressed by partially retained envelope or surrounding The fibrous tissue is separated, although small nerve branches in the vicinity are often found, but it is usually not easy to recognize that it is directly connected to the nerve.

Immunohistochemical examination: The cells in the mucus matrix were strongly positive for S-100 protein and type IV collagen, positive for neuron-specific enolase and Leu7 (CD57) antigen, and the epithelial membrane antigen was present when the envelope was retained. Positive reaction, axonal neurofilament staining was negative, and myxomatous matrix strongly positive for acid mucopolysaccharide staining.

Cellular sphincter mucus is an invasive lesion with unclear boundaries, involving most of the dermis, even involving subcutaneous tissue. The appearance of tumor growth is bundle-like, plexiform, nodular or nested. The tumor is mainly composed of epithelioid cells and large nuclei. It is oval in shape, rich in cytoplasm, and is not obvious in eosinophilic membrane. Chromatin is often concentrated on the nuclear membrane. There is a distinct nucleolus, and spindle cells can also be seen, especially when the cells form nests or swirls. Or oval, mitotic figures are obvious, there are varying degrees of cellular atypical, and multinucleated giant cells are also seen, usually lacking mucin-like substances, or clustering around individual cell nests, immunohistochemical examination, cell-type neuromyeloma Both -100 protein and HMB45 were negative for melanoma, as were Leu7 (CD57), type IV collagen and epithelial membrane antigen were negative or focally weakly positive, NK1/C3 neuron-specific enolase, smooth muscle-specific muscle The kinesin and CD34 antigens have a positive report of sporadic, and only clofied fibrin is often positive.

Diagnosis and differentiation of nerve sheath myxoma

According to the clinical manifestations, the characteristics of skin lesions, histopathological features, immunohistochemical staining can be diagnosed.

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