Sheep pox

Introduction to sheep pox Sheep pox (Qrf) is a purulent inflammation on the skin after the sheep is infected with poxvirus, and then transmitted to humans to cause sheep pox. basic knowledge The proportion of illness: 0.005% Susceptible people: no special people Mode of infection: contact spread Complications: pneumonia, arthritis

The cause of sheep pox

(1) Causes of the disease

Sheep pox is caused by a cylindrical poxvirus that has a woven appearance under an electron microscope and is a common disease in sheep.

Sheep pox virus is an ether-sensitive DNA virus. It is cylindrical under electron microscope and has a convex end. The center has a dense DNA core and a broad, lamellar capsid. Its size is 200×300 nm. Amniocytes and primitive rhesus monkey kidney cells grow on the culture. This virus mainly invades sheep. People are infected because they are directly exposed to the contaminated substances of sick sheep. Therefore, they are more common in shepherds, veterinarians and slaughterers. Reports of mutual infection, there is lifelong immunity after infection.

(two) pathogenesis

Sheep pox is caused by a cylindrical poxvirus with a woven appearance under electron microscope. It is a common disease in sheep. It mainly affects lambs. It is a contact infection. People are infected because they are directly exposed to the substances contaminated by diseased sheep. More common in shepherds, veterinarians and slaughterers, etc., there have been no reports of human infections between people. After infection, there is lifelong immunity. Viral inoculation succeeds in human beings, and human and animal damage is organized and cultured with virus growth.

Sheep pox prevention

1. Avoid contact with sheep and goats with sheep pox, and vaccinate the lambs live virus vaccine for 2 to 3 weeks for life-long immunity.

2, usually do a good job of sheep breeding management, often clean the sheepfold, keep it dry and clean.

3. When the sheep have already developed disease, immediately isolate the diseased sheep and disinfect the sheep house, the site, the equipment, and vaccinate the sheep that are not affected or adjacent to the threatened sheep.

4. Workers who prepare vaccines in the laboratory prevent self-inoculation.

Sheep pox complications Complications pneumonia

After the occurrence of sheep pox, complications are often accompanied, such as respiratory inflammation, pneumonia, arthritis, and gastroenteritis.

Sheep pox symptoms common symptoms rash papillary polymorphic erythematous rash pustule scars local lymphadenopathy toxemia

The incubation period is 5 to 6 days. It is a red or purple-red small papule at the beginning. It has a hard texture and will expand into a flat blister at the top. It can develop into a hemorrhagic bullous or pustule. The center can have a umbilical concave, and the size is 2 to 3 cm. Up to 5cm, in 24~48h, the surface of the blister is covered with thick pale brown eschar, and there is a special gray-white or purple halo around the sputum. The blister is surrounded by a blush, which becomes a papillary nodule and finally becomes Flat, dry, crusted and self-healing, the course of disease is usually 3 weeks, can also be 5 to 6 weeks, get permanent immunization, re-infection is more common in patients with low immune function, the number of lesions is not much, single or Several, occur in the exposed parts of the fingers, hands, forearms and face, in addition to local slight swelling and itching, no systemic symptoms or only slightly hot, local lymph nodes, some patients 2 weeks after the onset, A transient rash can occur in the trunk, and a polymorphous erythematous rash can appear on the extremities of the extremities. A large outward-grown skin lesion, similar to a purulent granuloma or a malignant tumor, can be seen in patients with low immunity or AD. Occasionally viremia, Now a wide range of pimples, blisters or bullous skin lesions.

According to the history of exposure, typical rash, self-healing process, generally not difficult to diagnose, if suspected, the damaged molting or biopsy tissue can be observed under the electron microscope, if the virus inclusion body can be clearly diagnosed, the virus growth in tissue culture slow.

Sheep pox inspection

1. The peripheral blood leukocyte count can be temporarily increased, and the lymphocytes are relatively increased.

2. Serum antibody test Neutralizing antibodies can be found in the serum of goats and patients during recovery.

3. Electron microscopy examination of sheep and pox virus can be seen in the lesions and lesions.

4. Histopathological epidermis is characterized by intracellular and intercellular edema, vacuolization and balloon degeneration. The dermis has dense cell infiltration. The central part is tissue cells and macrophages, surrounded by lymphocytes and plasma cells. The nucleation of leukocytes infiltrates, and there are many small blood vessels in which the endothelial cells proliferate and swell. The eosinophilic inclusion bodies can be seen in the cytoplasm of dermal endothelial cells.

Sheep pox diagnosis

1. The milkman's nodule is sick when he comes into contact with the sick cow. The milkmaid is more common. The rash is herpes and nodules, and there is no eschar.

2. Ring granulomatous papule nodules are closely arranged into a ring shape, which looks like beaded, smooth surface, more common in children and young people, and pathological changes are characteristic.

3. Skin fibrosarcoma is good for the trunk, especially for the front chest. It is more common in middle-aged people. The early rash is a plurality of hard nodules on the plaque. It is easy to be broken and accompanied by hemorrhage in the late stage. The fibroblasts are arranged in a special tissue. It has a vortex, fan or wheel structure and is of diagnostic value.

Huge outward-growth lesions should be differentiated from pyogenic granulomas or malignancies.

The material in this site is intended to be of general informational use and is not intended to constitute medical advice, probable diagnosis, or recommended treatments.