Oral condyloma acuminatum

Introduction to oral condyloma Condyloma acuminata is an infectious disease caused by human papillomavirus (HPV). It is naturally transmitted mainly by sexual contact, and it can also be indirectly infected through public baths, swimming pools, toilets and the like. In addition, HPV is easy to grow and reproduce in the warm and humid parts of the human body, so the external genitalia, perianal and other parts are the predilection sites of genital warts. Oral condyloma acuminata is located at the sublingual ligament, on both sides of the tongue, and in the throat. When the corpus callosum is large, there will be hoarseness, difficulty in swallowing, and symptoms of throat discomfort. The lesions and the surrounding tongue are located in the tie, the rash is raised like a papillary, cauliflower-like, cockscomb or cobblestone-like appearance, the mung bean's bean size, the boundaries are clear, and the number varies from 1 to 10. Color symptoms of oral condyloma: rash, red or pale red, easy to bleed. Under the microscope, it can be seen that the epidermis of the condyloma acuminatum is diffuse keratosis, and it shows that papillary tumor-like hyperplasia, mast cell ear, showing vacuolar cells, skin surface telangiectasia, chronic inflammatory cell infiltration. basic knowledge The proportion of illness: 0.001% Susceptible people: no specific population Mode of transmission: sexual transmission mother-to-child transmission Complications: swelling, malignant tumor

Oral condyloma

Virus infection (90%):

Condyloma acuminata is an infectious disease caused by human papillomavirus (HPV). Oral genital warts are mainly transmitted by sexual contact, and can also be indirectly infected through public baths, swimming pools, toilets, and the like. There have been oral sex during or after the onset of the disease, and the target of oral sex is the person with genital warts, or is in the incubation period, the chance of infection will increase, because the above conditions will cause local congestion, and resistance. The decline, this will give the virus a chance to get infected.

Oral condyloma acuminata prevention

The most effective preventive method for this disease is to cleanse yourself and prevent good sexual habits when ending the extramarital sex. Once the traces of condyloma acuminata are found, early treatment must not be adversely affected by illness.

There are a few points to note when communicating with genital warts:

1, husband and wife infected each other

If both husband and wife suffer from genital warts at the same time, both parties should be treated at the same time. This is because only one treatment is ineffective, and the treatment is not thorough, and it will cause mutual infection in the usual sexual life. Therefore, genital warts must be treated simultaneously by both husband and wife.

2, friction

In patients with genital warts, the mutual friction of the organs causes the skin to produce small, invisible damage to the naked eye. If one of the viruses has a virus, it can enter the other skin at any time, leading to infection.

3. Mother-to-child transmission

The onset of condyloma acuminata causes female patients to become pregnant. If a pregnant woman has genital warts, it is likely to be transmitted to her own fetus. At the same time, more attention should be paid to cesarean section in order to avoid infection of your own fetus during childbirth. Do not bathe with the baby in the pot after birth.

4, self-inoculation

Condyloma acuminata will cause itching during the onset of the disease, so many patients will often scratch the affected area. If you do not pay attention to hygiene, you will be exposed to other parts of your body after scratching.

Oral condyloma Complications, swelling, malignant tumor

1, ulcers, bleeding lesions increase, increase, can cause local foreign body and discomfort. Because the site of the attack is mostly in the foreskin, the urethra, the perianal area, etc., these parts are easily infected by microorganisms, causing ulceration, suppuration, bleeding, pain and swelling of the lesion.

2, affecting the quality of the birth of pregnant women with genital warts, during childbirth, the baby through the birth canal may be infected, causing infants and children to bite the suction.

3. Indirect contact between the eyes and the mouth through direct contact or contaminated articles can cause papilloma of the conjunctiva and papilloma of the oral mucosa.

4, causing deterioration of malignant tumors is the most serious complication of condyloma acuminata. HPV16, 18 type infection after oral condyloma acuminata treatment network, if the treatment is not timely, it is likely to cause cancer, cervical cancer and other malignant tumors in the future, early thorough treatment is the most effective way to prevent the deterioration of condyloma acuminata.

Oral condyloma acumin symptoms common symptoms fever accompanied by rash rash is a sore throat pain proliferative sound hoarse lips bleeding dysphagia

The lesions and the surrounding tongue are located in the tie, the rash is raised like a papillary, cauliflower-like, cockscomb or cobblestone-like appearance, the mung bean's bean size, the boundaries are clear, and the number varies from 1 to 10. Color symptoms of oral condyloma: rash, red or pale red, easy to bleed. Under the microscope, it can be seen that the epidermis of the condyloma acuminatum is diffuse keratosis, and it shows that papillary tumor-like hyperplasia, mast cell ear, showing vacuolar cells, skin surface telangiectasia, chronic inflammatory cell infiltration.

Examination of oral condyloma acuminata

First, the acetic acid white test : the body is coated with 3-5% acetic acid for 2-5 minutes, the lesions become white and slightly elevated, and the anal lesion may take 15 minutes. The principle of this test is the result of whitening of proteins and acids. The keratin produced by HPV-infected cells is different from that of normal uninfected epithelial cells, and only the former can be decolorized by acetic acid. The sensitivity of the acetic acid white test for detecting HPV is high, and it is better than the conventional examination to observe histological changes. Occasionally, false positives and false positive whitening signs appear in cases of epithelial thickening or traumatic scuffing, which appear to be unclear and irregular. The US CDC suggested that the acetic acid white test is not a specific test, and false positives are more common.

Second, immunohistological examination: commonly used peroxidase anti-peroxidase method (PAP), showing the viral protein in the wet sputum to prove that there is a viral antigen in the sputum damage. When the HPV protein is positive, a pale red weak positive reaction may occur in superficial epithelial cells of condyloma acuminata.

3. Histochemical examination : A small amount of diseased tissue was taken to make a smear, and stained with an antibody specific for human papillomavirus. If there is a viral antigen in the lesion, the antigen and antibody bind. In the peroxidase antiperoxidase (PAP) method, the core can be stained red. This method is specific and rapid, and is helpful for diagnosis.

Fourth, pathological examination: mainly for parakeratosis, high abdomen hypertrophy, papillary hyperplasia, epidermal thickening, prolongation, its degree of hyperplasia may resemble pseudoepithelial neoplasia. The thorn cells and basal cells have a considerable number of nuclear divisions, which are quite cancerous. However, the cells are arranged in a regular manner, and the boundary between the proliferating epithelium and the dermis is clear. It is characterized by obvious vacuolization in the upper cells of the granule layer and the thorn layer. Such vacuolar cells are larger than normal, the cytoplasm is lightly colored, and the center has large and round, deep basophilic nuclei. Often dermal edema, telangiectasia, and dense, chronic inflammatory infiltration around. Bushke-loewenstein's huge condyloma acuminata, the epidermis grows extremely downward, replacing the tissue below it, easily mixed with squamous cells, so multiple biopsies are required. If there is a tendency to develop slowly, it is a process of low-grade malignant transformation, so-called sickle cancer.

V. Genetic diagnosis: Up to now, HPV is difficult to detect with traditional virus culture and serological techniques. The main experimental diagnostic technique is nucleic acid hybridization. The PCR method developed in recent years has the advantages of being specific, sensitive, simple and rapid, and opens up a new way for HPV detection.

Diagnosis and differentiation of oral condyloma acuminatum

diagnosis

Diagnosis can be based on medical history, clinical symptoms, and laboratory tests.

Differential diagnosis

1. Villi-like labia minora: also known as pseudo-dampness, which occurs in the inner side of the labia minora of young women, around the vestibule of the vagina and the urethra. It is symmetrically densely distributed with white or reddish papules of 1 to 2 mm in diameter and has a smooth surface. It may be in the form of a villus, a fish or a polyp. No obvious symptoms, occasional itching. The acetic acid white test was negative.

2. Pearly penile papules: The rash is located in the coronal sulcus of the glans. It can be seen as pearly, conical or irregular white, yellowish white or skin pimples. It can be translucent, smooth and hard, with each other between the papules. They do not merge with each other and are regularly arranged along the coronal groove into one to several rows. The acetic acid white test was negative.

3. Sebaceous gland ectopic disease: glans, foreskin or labia minora can be seen in the size of the miliary, isolated and slightly uplifted, in groups or in pieces of yellow-white or yellowish papules, no symptoms. Histologically, each papule is composed of a small group of small mature sebaceous gland lobes, which surround the sebaceous gland duct. The acetic acid white test was negative.

4. Penile collateral papular fibroma: a white or yellow-white miliary papule that occurs symmetrically on either side of the penile ligament, single or several, soft, smooth, and non-fused. According to the medical history and the negative test of acetic acid white, it can be differentiated from condyloma acuminata.

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