Hereditary symmetric pigmentary disorder

Introduction to hereditary symmetrical pigment abnormalities Hereditary symmetrical dysplasia (hereditary symmetric dyschromatosis) is also known as symmetrical apical pigmentation (acropigmentatiosymmetrica), symmetrical apex and reticular leukoplakia (leucopathiapunctataetreticularissymmetrica), Dohi symmetrical acromosis (acroigmentationsymmetricaofDohi). When young, the clinical manifestations are punctate pigmentation spots in the hands, back of the feet and limbs. basic knowledge The proportion of illness: 0.003% Susceptible people: no special people Mode of infection: non-infectious Complications: pigmentation spots

Causes of hereditary symmetrical pigment abnormalities

(1) Causes of the disease

It is a rare autosomal dominant inheritance, mainly found in Asians, and can have multiple hereditary types, which are related to the marriage of close relatives.

(two) pathogenesis

The pathogenesis is still unclear.

Hereditary symmetrical pigment abnormality prevention

The disease belongs to congenital chromosomal abnormal disease. Secondly, the disease may have certain correlation with environmental factors, genetic factors, dietary factors, mood and nutrition during pregnancy, so the disease cannot be directly prevented. Early detection, early diagnosis, and early treatment are important for preventing this disease. Regular checkups during pregnancy should be done to supplement adequate folic acid and other vitamins, which can also reduce the incidence of this disease to some extent.

Hereditary symmetry dysepsia complications Complications

The disease generally does not directly induce other diseases. However, due to the disease, the color and shape of the skin are changed. Therefore, for patients with mental depression, the disease may be destroyed by the integrity of the skin color, so that depression may be induced. And the disease is a hereditary disease, so it can be combined with the presence of other congenital diseases, such as congenital glycogenosis.

Hereditary Symmetrical Pigment Symptoms Symptoms Common Symptoms Pigment abnormal pigmentation Freckle pigmentation level Palm pleats (through hand)

Occurs at the end of the extremities, the rash is a brown spot from the point to the lentils, not blending, like freckles, the color is deepened after sun exposure in summer, the light is limited to the hands and feet, the back; the heavy can occur on the face, forearm, chest and back , abdomen; oral mucosa can also rash, no symptoms, reticular leukoplakia and pigment spots between the back of the hand and foot, the disease more men than women, infancy, the same patient in the same family, and some children can live Depigmentation occurs at the posterior nail fold or at the distal end of the finger.

Examination of hereditary symmetrical pigment abnormalities

Histopathology: pigmentation granules in the basal layer of the epidermis in the pigmentation area increased, phagocytic cells in the dermis increased, and hypopigmented areas were less.

Diagnosis and identification of hereditary symmetrical pigment abnormalities

According to the clinical manifestations, the characteristics of skin lesions and histopathological features can be diagnosed.

It should be differentiated from Kitamura reticular acral pigmentation and pigmented dry skin disease.

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