Extracellular cholesterol syndrome in children

Introduction to extracellular cholesterol syndrome in children Extracellular cholesterosis syndrome (extracellular cholesterolesterosis), also known as Urbach syndrome. It was first reported by Urbach in 1932 that the back of the hand and the limbs were purple-red and the center was a symptom of brown-yellow plaque nodules. The histological examination of the lesion showed extracellular cholesterol deposition, hence the name of the cell. External cholesterolosis. It is currently believed that this symptom is a disease of chronic vasculitis with persistent erythema. basic knowledge The proportion of illness: 0.002% Susceptible people: children Mode of infection: non-infectious complication:

Causes of extracellular cholesterol syndrome in children

(1) Causes of the disease

The cause of this disease is unknown, and is associated with chronic vasculitis of bacterial infection.

(two) pathogenesis

Some scholars believe that this disease is a chronic vasculitis, often showing vascular endothelial swelling, and varying degrees of vascular inflammatory changes, the dermis has dense diffuse neutral and eosinophil infiltration, and extracellular cholesterol, this kind of The occurrence of chronic vasculitis is related to bacterial infection and its toxin action. Some people think that this symptom is a variant of erythema elevatum endurance (also known as Bury syndrome) or its subtype.

Pediatric extracellular cholesterol syndrome prevention

The occurrence of this disease is related to personal physique, and attention should be paid to the prevention of infectious diseases.

Pediatric extracellular cholesterol syndrome complications Complication

Can cause hepatosplenomegaly and impaired function.

Pediatric extracellular cholesterol syndrome symptoms common symptoms nodular papules liver splenomegaly

The symptoms can be affected in children and all ages, clinically divided into two types:

1. Type I is characterized by groovy plaques and nodules, which are purple-red with a central region of brown, often occurring in the back of the hands and feet, and lesions can also affect the limbs, chest, back, ears, tongue and other parts.

2. Type II is characterized by lavender spots, with yellow nodules and papules scattered between them, some with mottled pigmentation, exfoliation of the epidermis, and a peculiar appearance, sometimes resembling polymorphic erythema.

Both types have hepatosplenomegaly, and the course of the disease is slow, which may cause dysfunction, but it is mild, and may be relieved naturally after a few years.

Examination of extracellular cholesterol syndrome in children

There may be an increase in amino aciduria and immunoglobulin.

Pathological examination, skin erythema biopsy showed vascular endothelial swelling and varying degrees of vascular inflammatory changes, dermal diffuse neutral and eosinophil infiltration, and extracellular cholesterol.

Abdominal B-ultrasound should be performed, and hepatosplenomegaly can be found.

Diagnosis and diagnosis of extracellular cholesterol syndrome in children

According to the above clinical features, this symptom can be confirmed by combining laboratory examination and skin lesion biopsy.

Different from other similar manifestations of rash, laboratory pathological examination can help diagnose.

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