Vulvar neurofibromas

Introduction to vulvar neurofibroma Vulvar neurofibroma is an isolated mass, often located in the labia majora. Vulvar neurofibroma is often part of the systemic multiple neurofibromatosis, with approximately 18% of neurofibroma involving the vulva. It grows slowly and usually has no pain after puberty, rarely malignant, but it increases significantly during pregnancy. Neurofibromas are divided into: 1. Multiple neurofibromas. 2. Isolated neurofibromatosis. 3. Localized neurofibromas. basic knowledge Sickness ratio: 0.0001% Susceptible people: women Mode of infection: non-infectious Complications: neurofibroma

Causes of vulvar neurofibroma

(1) Causes of the disease

Whether the vulvar neurofibroma is derived from the ectodermal nerve sheath or the mesoderm nerve sheath is still controversial and may be prone to Schwann cells derived from the ectoderm.

(two) pathogenesis

The tumor is located in the dermis and often invades into the subcutaneous adipose tissue. The tumor can be single or multiple, generally <3cm, with clear edges, often no obvious envelope, and the cut surface is pink and uniform.

Microscopically, there are mainly wavy eosinophils (neural sheath cells and nerve bundle connective tissue cells). Most of the collagen-free fiber bundles are arranged in a direction, uniform in size, in a threaded or spiral structure, and connective tissue cells and collagen fibers are scattered. The nerve sheath cells are arranged in bundles, which are in the form of strips or spirals. The interstitial fibers and blood vessels are visible in the interstitial cells. The tumor cells are elongated or fusiform or deep-stained.

Vulvar neurofibroma prevention

1, regular physical examination: to achieve early detection, early diagnosis, early treatment.

2, do a good job: to prevent malignant transformation.

3, pay attention to personal hygiene, especially the health of the genitals during menstruation and puerperium.

4, enhance physical fitness, improve their own immunity: pay attention to work and rest, more to participate in physical exercise, eat more fresh fruits and vegetables rich in vitamins.

Vulvar neurofibroma complications Complications

Multiple neurofibromas are found in other parts of the body.

Symptoms of vulvar neurofibroma Common symptoms Large labia majora or anus large... Nodular growth slow subcutaneous nodule coffee spots

Vulvar nerve fibroma is generally asymptomatic, slow-growing, rarely malignant, but this tumor can be significantly enlarged during pregnancy. Sometimes the tumor is discomfort when it is large, which can occur in any tissue, often occurs in the labia, single-shot The tumor is small, soft, often with pedicles, and the surface is pigmented. The tumor protrudes prominently from the surface of the skin, forming a spherical or pedicled cystic mass. The tumor can be pressed into the skin with a fingertip. Apparent elasticity, coffee spots on the skin, ranging in size, from rice grain size to huge overhanging tumors, the number is more or scattered, some scholars believe that more than 6 cm diameter coffee spots have more than 6 diagnoses of multiple neurofibromatosis.

1. Solitary neurofibromatosis (solitaryneurofibroma): about 1cm in diameter, without multiple systemic lesions.

2. Localized neurofibroma: The disease is characterized by multiple isolated neurofibromas clustered together.

The disease is mainly in childhood, with family history, coffee spots, soft tumors and other systemic damage. If necessary, combined with pathological examination, the general diagnosis is not difficult.

Examination of vulvar neurofibroma

Vaginal secretion examination, tumor marker examination excludes other diseases.

Histopathological examination.

Diagnosis and diagnosis of vulvar neurofibroma

Diagnostic examination

1. History: There may be a history of neurofibroma in other parts of the body.

2. Symptoms: Multiple subcutaneous nodules were found throughout the body, and the vulvar subcutaneous nodules were one of them.

3. Signs: subcutaneous nodules are soft and vary in size. The surface of the skin is yellow-brown pigmented, and a small number of tumors appear as non-subcutaneous nodules, but prominently protrude from the surface of the skin to form a spherical or pedicled sac. A lump, soft.

Differential diagnosis

1. Invasive angiomyxoma: clear boundaries, rich in cells, with prominent thin-walled blood vessels, surrounded by fusiform, plasma cells aggregate.

2. Low-grade malignant schwannomas: high cell-like, heterogeneous components can occur, and a /10HPF nuclear division occurs, which is one of the diagnostic malignant.

3. Vestibular gland cysts: Vulvar fibroids need to be differentiated from small vestibular gland cysts, and pathological examination can confirm the diagnosis.

4. Vulvar lipoma: The tumor is small and soft, similar to vulvar neurofibroma, but without pedicle, pathological biopsy can confirm.

5. Vulvar skin sputum: soft, pedicled, no obvious pigmentation, microscopically seen skin sputum consists of dermal connective tissue surrounded by the epidermis.

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