California encephalitis

California Encephalitis Introduction California encephalitis is a central nervous system disease caused by the antigen-associated California virus group. basic knowledge The proportion of illness: 0.005% Susceptible people: no special people Mode of infection: non-infectious Complications: respiratory failure edema

California encephalitis cause

(1) Causes of the disease

California encephalitis virus and La Crosse, Jamestown Canyon and snowshoe hare and other viruses are Bunia virus genus, can cause encephalitis.

(two) pathogenesis

After being bitten by an infected arthropod, the virus replicates in local tissues and local lymph nodes. The occurrence and persistence of viremia depends on the stage of viral replication in local tissues outside the nervous system, the speed at which the mononuclear-macrophage system clears the virus, and the specificity. The emergence of sexual antibodies, and thus the clinical manifestations of large differences.

The brain is filled with blood and water, and has extensive neuronal degeneration. There are multiple hemorrhagic foci in the brain tissue. Microscopic examination shows degeneration and necrosis of nerve cells, lymphocytes around the blood vessels, monocytes and polymorphonuclear leukocytes infiltrate, forming " Perivascular sleeves, some glial cell hyperplasia and polymorphonuclear leukocyte accumulation form nodules, lesions mainly found in the basal ganglia of the brain, brain gray matter and white matter, can also invade the cerebellum and spinal cord.

California encephalitis prevention

Anti-mosquito and anti-mosquito are the main preventive measures, and there is no vaccine application.

California encephalitis complications Complications, respiratory failure, edema

Consequent respiratory failure, optic disc edema, increased intracranial pressure.

California symptoms of brain inflammation Common symptoms Respiratory failure Gastrointestinal symptoms Convulsions Sore throat coma

The incubation period is 5 to 10 days. The mild ones have fever, headache, sore throat and gastrointestinal symptoms. The symptoms and signs of the nervous system appear within 13 days, which can be resolved within 7 days. The severe cases have convulsions in 24 to 48 hours, coma and even the center. Sexual respiratory failure, may have optic disc edema, but increased intracranial pressure is rare, the mortality rate <1%, generally no neurological and mental sequelae.

California encephalitis check

Peripheral blood leukocyte counts are moderately elevated, sometimes up to 30 × 109 / L.

Using convection electrophoresis and electrocoagulation inhibition test, the antibody titer was increased by 4 times or more, and it can also be detected by antibody capture ELISA.

California encephalitis diagnosis and identification

The diagnosis depends on serological examination. Double serum is used, and the antibody titer is detected by convection electrophoresis and electrocoagulation inhibition test, and the antibody titer is increased by 4 times or more. It can also be detected by antibody capture ELISA.

The disease needs to be differentiated from Western equine encephalitis, herpes simplex encephalitis, and JE.

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