Transient acantholytic skin disease

Introduction to transient echinoderma lysis Transientacantholyticdermatosis, also known as Grover disease (Groverdisease), is apopular acupuncture (popularacantholysis), first reported by Grover in 1970, is a spontaneously relieved adult acanthosis Solve and treat dysplastic diseases. basic knowledge The proportion of sickness: 0.003%-0.007% Susceptible people: no special people Mode of infection: non-infectious Complications: pruritus

Transient acanthosis to resolve the cause of skin diseases

(1) Causes of the disease

The cause is unknown. There is no evidence related to heredity in this disease, and there are no reports related to infection factors. These patients often have sebum deficiency and there is no other relevant content.

(two) pathogenesis

The pathogenesis is still unclear, and there are no other relevant descriptions at present.

Transient acanthosis to prevent skin disease

The disease is often relieved within weeks to months, sometimes in older patients for a longer period of time, usually lasting about 2 months, and individual cases can last for several years.

Transient acanthosis to resolve skin disease complications Complications pruritus

There are usually no special complications.

Transient acanthosis to relieve skin disease symptoms Common symptoms Itching papules Skin blisters or bullae damage scarring

The skin lesions are diffusely distributed in the trunk area, which occurs in the chest, shoulder area and upper abdomen. It can also occur in the rubbing area and limbs. It is loose and easy to break the blisters, and quickly forms scars, sometimes forming keratinized damage, usually 1cm. The size can also be seen in the exudative papules, the surface is smooth or crusted. In short, the skin lesions are various in shape, and the damage is sometimes arranged in groups, and the symptoms are markedly itchy.

Some patients may have elevated levels of eosinophils and serum IgE, and acantholytic cells may be seen on the cell smear.

The disease is often relieved within weeks to months, sometimes in older patients for a longer period of time, so-called persistent or popular acantholytic dermatosis sun exposure can stimulate the disease It usually lasts for about 2 months and individual cases can last for several years.

Transient acanthosis to resolve skin disease

Histopathology: characterized by the release of blisters in the epidermis, the blisters are located under the horn layer or on the basal cell layer, sometimes accompanied by sponge formation, epidermal cell reticular degeneration and keratosis, histological manifestations of Daryl Disease (Darier disease), characteristic of family-like benign chronic pemphigus (Hailey-Hailey disease), pemphigus vulgaris or deciduous pemphigus and sponge-forming acantholytic dermatitis.

Immunopathology: Both direct immunofluorescence and indirect immunofluorescence were negative.

Diagnosis and identification of transient echinodermolytic skin disease

Mainly rely on the exclusion of other possible diseases, combined with the age of clinical onset, skin lesions are polymorphic, severe itching, histopathological changes have acanthosis, negative immunofluorescence can help diagnosis.

The differential diagnosis should be differentiated from subacute simple pruritus, ascariasis, sputum, folliculitis, follicular eczema, red millet rash, etc. When the lesion is confined to the trunk, there is obvious itching, and for the elderly, it should be considered Herpes-like dermatitis is identified.

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