Concentrated bile syndrome

Introduction to Concentrated Bile Syndrome Concentrated bile syndrome, also known as congenital immune hemolytic hepatitis, biliary thrombosis syndrome, biliary concentrating syndrome, refers to the obvious obstructive jaundice after hemolytic disease in newborns. Anemia is gradually aggravated within 1 to 2 weeks after birth, which is not proportional to the degree of jaundice, hepatosplenomegaly, reticulocyte increase, some patients have positive Coombs test, or Rh factor difference between mother and baby. Generally appear 2 days after birth, lasting for 3 weeks, varying degrees of severity, obstructive, fecal clay color. basic knowledge The proportion of illness: the incidence rate is about 0.001% - 0.004% Susceptible population: newborn Mode of infection: non-infectious Complications: neonatal hemolytic disease

Concentrated bile syndrome

genetic factors:

A variety of neonatal hemolysis can cause this disease. Due to excessive hemolysis, bilirubin in the bile increases, causing an increase in the concentration of bile, which is then concentrated to form a bile plug. These biliary plugs aggregate to form a bile plug, which causes obstructive jaundice. In addition, high concentrations of bilirubin can cause hepatocyte swelling, leading to secondary intrahepatic cholestasis, and the nature of the extrahepatic obstruction caused by bilirubin stones is different.

Pathogenesis

A variety of neonatal hemolysis can cause this disease. Due to excessive hemolysis, bilirubin in the bile increases, causing an increase in the concentration of bile, which is then concentrated to form a bile plug. These biliary plugs aggregate to form a bile plug, which causes obstructive jaundice. In addition, high concentrations of bilirubin can cause hepatocyte swelling, leading to secondary intrahepatic cholestasis, and the nature of the extrahepatic obstruction caused by bilirubin stones is different.

Concentrated bile syndrome prevention

The disease is mainly caused by Rh incompatibility or AB blood type or other blood type incompatibility, so it should be actively carried out for marriage and pregnancy tests.

Concentrated bile syndrome complications Complications, neonatal hemolytic disease

It is easy to complicated with intrahepatic cholestasis, neonatal hemolysis and other diseases.

Concentrated symptoms of bile syndrome Common symptoms Continuous fever bile reflux bile retention jaundice gallbladder dyskinesia gallbladder hydrops

1. Hemolysis symptoms: Anemia is gradually aggravated within 1 to 2 weeks after birth, which is not proportional to the degree of jaundice, hepatosplenomegaly, reticulocyte increase, some patients have positive Coombs test, or Rh factor difference between mother and baby.

2, obstructive jaundice: generally appeared 2 days after birth, lasting 3 weeks, varying degrees of severity, obstructive; fecal clay color.

Concentrated bile syndrome test

Urinary bilirubin positive, urinary biliary negative, serum bilirubin concentration increased, combined with bilirubin.

Diagnosis and identification of concentrated bile syndrome

Can be diagnosed based on clinical symptoms and laboratory tests.

Intrinsic should be differentiated from organic extrahepatic biliary obstruction such as neonatal hepatitis and congenital biliary atresia.

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