Foreign body granuloma

Introduction to foreign body granuloma Foreign body granuloma (foreginbody granuloma) enters human skin tissue by various substances of non-organism tissue, causing tissue reaction (skin foreign body reaction), and its structure is granulomatous inflammatory reaction. basic knowledge The proportion of illness: 0.003% Susceptible people: no special people Mode of infection: non-infectious complication:

Cause of foreign body granuloma

(1) Causes of the disease

There are many kinds of substances causing granulomatous reactions of foreign bodies in the skin. Generalized foreign bodies include metal fragments, non-metallic ores, glass, vegetable starch, chemical fiber, cotton silk material, parasitic larvae, fungi, physical explosive dust, and hard-to-absorb drugs. Sexual oily or irritating chemicals or endogenous keratins, cysts or teratoma rupture, tissue necrosis and calcification deposits, etc., can cause inflammation granuloma reaction.

(two) pathogenesis

The entry of various substances of non-organism into the human skin tissue causes the body's tissue reaction (skin foreign body reaction), and its structure is a granulomatous inflammatory reaction.

Foreign body granuloma prevention

Sometimes a hard mass or nodule can form due to a subcutaneous implant (such as an oil injection) that does not disappear or cause local atrophy for many years.

Foreign body granuloma complications Complication

There are nodules, plaques, and pigmentation.

Symptoms of foreign body granuloma Common symptoms Inflammatory granulomatous granuloma Infectious granuloma Skin atrophy and hyperpigmentation nodular reticulocyte cell papular tissue necrosis

Foreign body granuloma is an allergic reaction caused by foreign body, which occurs mostly in people with allergic properties. Usually, foreign bodies enter the body to the rash for a long time, ranging from several months to several years, such as silicide (cement, sand and gravel). , glass, etc. can occur in 10 years or so before the rash reaction, skin lesions vary depending on the type, nature and invasiveness of foreign bodies, common with papules, nodules, plaques, pigmentation, inflammation and inflammatory cell infiltration Etc., the local skin color can be red or purple, can also be normal skin color, hard skin damage, impossible to self-elimination, a small number of inflammatory reactions or tissue necrosis, can self-destruction of foreign bodies or necrosis, sometimes due to subcutaneous implantation The substance (such as an injection of oil) forms a hard mass or nodule that does not disappear or cause local atrophy for many years.

Foreign body granuloma examination

Histopathology:

1. Typical foreign body reaction is macrophage and foreign body giant cells surrounding foreign bodies, phagocytic foreign bodies can be seen in the cytoplasm, and foreign bodies such as sutures, liquid paraffin oil, silicon salts, hair, etc. can be seen to cause foreign body reaction.

2. Allergic reactions to foreign bodies, tuberculous nodules composed of epithelial cells, giant cells and caseous necrosis, but lack or little phagocytosis of foreign bodies, cobalt, sputum or tattoo pigments can cause allergic reactions to foreign bodies.

3. Some specific foreign body granuloma, such as tattoo granuloma visible pigment particles, silicon granuloma is non-tuberculous granuloma, inflammation infiltration of most macrophages and multinucleated cells, visible acicular silicon crystals with strong refractive index.

Diagnosis and differentiation of foreign body granuloma

diagnosis

According to the clinical manifestations, the characteristics of skin lesions and histopathological features can be diagnosed.

Differential diagnosis

The disease does not need to be differentiated from other diseases.

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