Chronic mucocutaneous candidiasis

Introduction to chronic mucocutaneous candidiasis Chronic mucocutaneous candidiasis (chronic mucocutaneous candidiasis) is mainly caused by cellular immunodeficiency, while humoral immunity is mostly hyperactive. It belongs to primary cellular immunodeficiency disease. basic knowledge Sickness ratio: 0.0001% Susceptible people: no special people Mode of infection: non-infectious Complications: Diabetes Hypoparathyroidism Iron deficiency anemia Vitamin A deficiency

Causes of chronic mucocutaneous candidiasis

(1) Causes of the disease

The disease is autosomal recessive or dominant.

(two) pathogenesis

The pathogenesis is still unclear and may be autosomal recessive or dominant.

Chronic mucosal cutaneous candidiasis prevention

There are no effective preventive measures for this disease. Prevention is limited to genetic counseling of known genetically identifiable genes. Prenatal diagnosis of cultured amniotic fluid cells or fetal blood can be used for a few immunodeficiencies, such as X-linked gamma-free spheres. Proteinemia, Wiskott-Aldrich syndrome, most severe combined immunodeficiency, with adenosine deaminase deficiency and chronic granulomatous disease, gender testing helps to exclude X-linked defects, in some primary immunodeficiencies Heterozygotes were detected. Early detection and early diagnosis are the key to the prevention and treatment of this disease.

Chronic mucosal cutaneous candidiasis complications Complications Diabetic hypogonadism Iron deficiency anemia Vitamin A deficiency

Diabetes, hypoparathyroidism, Edison disease, iron deficiency anemia, vitamin A deficiency.

Chronic mucocutaneous candidiasis symptoms Common symptoms Candida infection scaly parathyroid function can reduce granuloma

Patients may have chronic recurrent candida infections of the skin, mucous membranes and claws, such as thrush, vaginitis, etc. Skin lesions are more common in the face and extremities, with a slightly elevated erythema, accompanied by keratinous hyperplasia, scales and Candida. Sexual granuloma, facial, forehead and scalp lesions often covered with thick keratinization, significant swelling around the nail, deck hypertrophy, distortion and destruction, internal organs are not tired, combined with idiopathic endocrine abnormalities such as diabetes, Hypoparathyroidism (88%) and Edison disease (60%), iron deficiency anemia (16%) and vitamin A deficiency.

Chronic mucosal cutaneous candidiasis

Immunological examination: Most patients have mild T cell dysfunction, but the total number of lymphocytes, the total number of T cells and lymphocyte mitogens such as PHA are normal, and only respond to the delayed skin allergy test of Candida antigen. Delayed skin allergic reaction to other various antigens is normal, the number of B cells and humoral immune function is normal, and there is normal serum immunoglobulin content.

Histological examination: Histological examination of lesions showed Candida granulomatous manifestations.

Diagnosis and identification of chronic mucosal cutaneous candidiasis

Chronic mucocutaneous candidiasis belongs to the primary immunodeficiency disease and should be differentiated from secondary immunodeficiency disease: secondary immunodeficiency disease, including infection, malignant tumor, autoimmune disease, protein loss, insufficient immunoglobulin synthesis Lymphocyte loss and certain other diseases and immunosuppressive therapies. Secondary immunodeficiency disease can be temporary, and when the primary disease is treated, the immune defect can return to normal; it can also be persistent. Secondary immunodeficiency is often caused by multiple factors. For example, secondary immunodeficiency disease associated with cancer can be caused by factors such as tumor, anti-cancer treatment and malnutrition.

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