Drug-induced respiratory failure

Introduction to drug-induced respiratory failure Drug-induced respiratory failure (DRF) refers to an acute respiratory failure caused by the application or treatment of a therapeutic or illicit drug. basic knowledge The proportion of illness: 0.001% Susceptible people: no special people Mode of infection: non-infectious Complications: pulmonary encephalopathy, gastrointestinal bleeding, shock, metabolic acidosis

Causes of drug-induced respiratory failure

Drug-induced respiratory failure is a serious form of drug-induced lung damage, mostly temporary and reversible, but it can also seriously impair the function of the lungs and even life-threatening. It is estimated that approximately 0.3% of patients who die during hospitalization are drug-related.

Pathology (30%):

There are many drugs that can induce or promote respiratory failure, and the mechanism of their occurrence is also different, but the basic changes mainly include acute non-cardiogenic pulmonary edema, bronchospasm, central or peripheral alveolar hypoventilation and alveolar hemorrhage, etc. The exact mechanism of these pathological changes is unclear and may be related to the direct toxic effects of the drug on alveolar capillary endothelial cells or their indirect inflammation or immune response.

Drugs (30%):

There are many drugs that can induce or promote respiratory failure.

Drug-induced respiratory failure prevention

In the rescue of respiratory failure, correction of hypoxia and CO2 retention, we must also pay attention to correct acid-base balance disorders and electrolyte imbalance, prevent gastrointestinal bleeding, maintain the normal function of the main organs, etc., to ensure the success and recovery of patients with respiratory failure.

Complications of drug-induced respiratory failure Complications, pulmonary encephalopathy, gastrointestinal hemorrhagic shock, metabolic acidosis

Complicated with pulmonary encephalopathy, gastrointestinal bleeding, shock and metabolic acidosis.

Symptoms of drug-induced respiratory failure Common symptoms After exercise, shortness of breath, dyspnea, irritability, gas diffusion disorder, lethargy, coma

Early clinical manifestations: When patients have symptoms such as difficulty breathing, shortness of breath, and difficulty in breathing, they should consider the possibility of respiratory failure. In severe cases, they may have mental confusion, irritability, lethargy, coma, superficial breathing or irregular breathing rhythm. Time blood gas analysis can confirm the diagnosis.

Examination of drug-induced respiratory failure

Blood gas analysis: It is commonly used in medicine to judge whether the body has acid-base balance imbalance and hypoxia and hypoxia.

X-ray chest X-ray: no abnormalities in the early stage, X-ray chest radiograph evolution is related to the severity of the disease.

Diagnosis and identification of drug-induced respiratory failure

diagnosis

The diagnosis of drug-induced respiratory failure should firstly identify the existence of respiratory failure. The diagnosis of respiratory failure is generally not difficult. The early diagnosis is mainly based on clinical manifestations. When patients have symptoms such as difficulty breathing, shortness of breath, and difficulty in breathing, respiratory failure should be considered. Possibly, serious cases may have mental confusion, irritability, lethargy, coma, superficial breathing or irregular breathing rhythm. At this time, blood gas analysis can confirm the diagnosis.

Differential diagnosis

The disease should be differentiated from cardiogenic pulmonary edema, pulmonary infection, pulmonary embolism, acute respiratory distress syndrome (ARDS) and cerebrovascular accident.

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