Primary vaginal malignant lymphoma

Introduction to primary vaginal lymphoma Primary vaginal malignant lymphoma is relatively rare. The age of onset is 19 to 79 years old, with an average age of 50 years. About 63% of patients with primary vaginal malignant lymphoma first show vaginal bleeding with vaginal discharge, and vaginal mass is usually found after several months. There may be pain in the lower abdomen, difficulty in sexual intercourse, and frequent urination, accompanied by fever and weight loss. 80% of vaginal examination can be seen vaginal masses, ranging in size from 2.5 to 12 cm, with obvious tenderness and partial surface mucosal ulcers. basic knowledge The proportion of illness: 0.05% - 0.08% Susceptible people: women Mode of infection: non-infectious Complications: cervical cancer

Primary vaginal lymphoma

(1) Causes of the disease

The etiology of primary vaginal malignant lymphoma is unclear and may be associated with local infection. Epstein-Barr virus can be found in patients with vulvar lymphoma, and the incidence of non-Hodgkin's disease lymphoma (NHL) is higher in HIV infection. The occurrence of the disease is closely related to immunosuppression. Some congenital immune defects are often complicated by malignant lymphoma. Some bacterial infections such as Helicobacter pylori (HP) and environmental factors such as insecticides can cause the use of pesticides. The disease occurs.

(two) pathogenesis

1. Histological classification One case of vaginal Hodgkin's disease reported by Perin et al. is nodular sclerosis. Due to the lack of stage and immunophenotyping in some vaginal non-Hodgkin's lymphoma data, most of them are obsolete classification criteria. Therefore, it is difficult to count the histological types, but the vast majority are diffuse large cell lymphomas. Vang et al found 8 cases of primary vaginal non-Hodge according to the revised European Classification of Lymphoma (REAL) criteria. Gold lymphoma is diffuse large B-cell lymphoma (DLBCL). Review of previous data suggest that approximately 83% of patients with primary vaginal NHL are DL-BCL, in addition to NK/T-cell lymphoma, follicular Lymphoma, marginal B-cell lymphoma, etc.

2. Immunohistochemical leukocyte common antigen CD45 is positive, B cell type also shows CD20, CD45RA, CD45RB, CD74 and CD79a positive, while T cell type is mostly CD3, CD4, CD45RO positive, NK/T cell lymphoma CD56 Positive for CD2 and positive for CD30 in Hodgkin's disease.

3. Molecular biology Southern blot or PCR method can detect the rearrangement of monoclonal immunoglobulin heavy chain gene in some B cell lymphomas, and some T cell lymphoma can detect TCR gene rearrangement.

Primary vaginal lymphoma prevention

1. Early patients have no symptoms, no masses, no pain, and most of the tongue and veins are normal. At this time, it is true and evil. Therefore, the traditional Chinese medicine prescription for attacking and exorcising evil is mainly used, and the medicine for assisting righteousness is taken orally. At the same time, Western medicine should be surgically removed.

2, the mid-term patient has developed symptoms of general malaise, the tumor has developed to a certain extent, is a true evil, or a positive and evil, need to attack and apply, should use surgery or targeted anticancer drug chemotherapy, radiotherapy, with Chinese medicine Anticancer preparation. To reduce toxic side effects, improve efficacy and quality of life.

Primary vaginal lymphoma complications Complications Cervical cancer

1, skeletal complications: clinical manifestations of local bone pain and secondary nerve compression symptoms.

2, hepatobiliary complications: If the patient's liver parenchyma is invaded, it can cause pain in the liver area.

3, gastrointestinal complications: gastrointestinal complications may occur in malignant lymphoma, mainly including loss of appetite, abdominal pain, diarrhea, abdominal mass, intestinal obstruction and bleeding.

4, skin complications: malignant lymphoma should also be careful about the occurrence of non-specific damage, common pruritus and pruritus.

5, tonsil and mouth, nose, throat complications: experts said that lymphoma invasion of the mouth, nose, throat, clinical dysphagia, nasal congestion, nasal discharge.

6, other complications: lymphoma can also infiltrate the pancreas, malabsorption syndrome occurs.

Primary vaginal lymphoma symptoms Common symptoms Sexual intercourse difficulties Fever lower abdomen pain Urinary vaginal bleeding

About 63% of patients with primary vaginal malignant lymphoma first show vaginal bleeding with vaginal discharge. Generally, vaginal mass is found after several months. It may have lower abdominal pain, difficulty in sexual intercourse, and frequent urination, occasionally with fever. And weight loss, vaginal examination 80% visible vaginal mass, ranging from 2.5 to 12cm, tenderness, partial surface mucosal ulcers, most of the tumor involving the surrounding tissues of the vagina, such as vaginal hernia, bladder, rectum, urethra and so on.

Three major symptoms of vaginal cancer in the early stage

1. Vaginal bleeding: more often in contact bleeding, usually after sex, or after the application of equipment and amenorrhea.

2. Vaginal drainage: abnormal drainage is mainly related to tumor necrotic tissue and infection. The discharged body can be watery, sometimes with rice soup, or mixed with blood.

3. Compression symptoms: When the advanced tumor is pressed against the adjacent organs, it can show the corresponding compression symptoms. Such as compression of the bladder, urethra, can show urgency, frequent urination, hematuria; when compressing the rectum, it can show difficulty in stool, urgency and weight; late patients can also show blood in the stool, the tumor penetrates the rectal symptoms.

Early diagnosis is an effective way to prevent and treat vaginal cancer. Older women and high-risk patients are best treated with Pap smear every year. Health products inquire about Breakline primary vaginal lymphoma treatment of traditional Chinese medicine.

The traditional Chinese medicine therapy for this disease is based on the principle of activating blood circulation to remove blood stasis, attacking and breaking the product, detoxification and dehumidification, but the specific application needs to be witnessed by the main legislation; in general, the disease should be based on surgical resection. The use of traditional Chinese medicine to break down the disease and cure the disease; in the middle and late stage depending on the condition, or attack-based, supplemented by supplements, or both offensive and defensive, grasp the measurement and reduce the majority of the decline. At the same time pay attention to the application of radiotherapy, chemotherapy And other methods of treatment.

Examination of primary vaginal lymphoma

Immunohistochemical monitoring and cytogenetic examination and histopathological examination. Colposcopy.

Diagnosis and diagnosis of primary vaginal lymphoma

About 63% of patients with primary vaginal malignant lymphoma first show vaginal bleeding with vaginal discharge, and vaginal mass is usually found after several months. There may be pain in the lower abdomen, difficulty in sexual intercourse, and frequent urination, occasionally accompanied by fever and weight loss.

Primary vaginal lymphoma must be differentiated from chronic vaginal inflammation, rhabdomyosarcoma, endometrial stromal sarcoma, and undifferentiated carcinoma.

The material in this site is intended to be of general informational use and is not intended to constitute medical advice, probable diagnosis, or recommended treatments.