Vulvar-vaginal-gingival syndrome

Introduction to vulvar-vaginal-gingival syndrome Vulvo-vaginal-gingival syndrome (VVGS) is a new type of multiple mucosal erosive lichen planus, which consists of chronic painful erosive vulvitis, erosive or keratotic vaginitis and erosive A syndrome consisting of a triad of vestibular gingivitis. basic knowledge The proportion of illness: the incidence rate is about 0.005%-0.007% Susceptible people: women Mode of infection: non-infectious Complications: neurasthenia

Vulvar-vaginal-gingival syndrome

(1) Causes of the disease

The cause of this disease is not fully understood. It has been thought to be related to mental factors and neurological disorders: such as excessive fatigue, mental depression, neurasthenia, nervousness, agitation and insomnia, but there are also those who are not the above-mentioned causes, so some people think that neurasthenia may be possible. It is a complication of this disease.

The disease is closely related to infection. Among the infection factors, it is more likely to be virological, and there have been reports of bacterial or fungal lesions in skin lesions, but most have not been confirmed.

In recent years, some scholars believe that this disease is an allergic or autoimmune disease.

A skin disease similar to this disease has recently been reported, which is caused by allergies to certain drugs or exposure to certain dyes.

In addition, nutritional disorders, endocrine disorders, gastrointestinal disorders, trauma including skin knife wounds and contact dermatitis, excessive drinking, strong tea and coffee, etc., may be the cause of the disease.

This disease has a family history.

(two) pathogenesis

In the fine lines of white, the typical lichen planus pathological changes can be seen; from the inflammation site, it is non-specific inflammation, there are a number of plasma cells; some are similar to viral infection, and a few patients have been diagnosed by electron microscopy; Immunofluorescence was used to confirm the presence of immunoglobulins and complement at the junction of the epidermal dermis of the patient, and no immune complex deposition.

Vulvar-vaginal-gingival syndrome prevention

At any time, psychological counseling and comfort are important for patients with lichen planus. Vulvar lesions are often chronic and may be malignant, and patients with lichen planus should be followed for a long time.

Vulvar-vaginal-gingival syndrome complications Complications, neurasthenia

Nervous breakdown.

Vulvar-vaginal-gingival syndrome symptoms common symptoms vulvar burning irritating vulvar pain vulvar atrophy dysparid difficulty sexual intercourse pain

The appearance of clinical symptoms is often not synchronized, and often several lesions have appeared one after another.

Eisen D studied 22 patients and found that among all patients with lichen planus, 16 had erosion and erythema, and 6 had white reticular lesions; in most patients, vulvovaginal lichen planus also showed erosion.

According to the clinical characteristics of the observation: 1 patients have erosion or dekeratinization lesions involving the vulva, vaginal or gingival mucosal surface; 2 often occur at a specific time; 3 only 1 or 2 of these 3 sites are involved.

Vulvar-vaginal-gingival syndrome examination

Whole blood count, liver function, cholesterol, triglyceride (triglyceride), electrolytes, urea nitrogen, creatinine and creatinine clearance should be monitored during the course of treatment.

Take a biopsy to confirm the diagnosis.

Diagnosis and differentiation of vulva-vaginal-gingival syndrome

Diagnostic criteria

1. Vulvitis: genital burning, check the vulva erythema, erosion, a striated white narrow band around the circumference, secondary vulvar adhesion, atrophy of the size of the labia, shaped like genital sclerosing moss, the condition can be periodically relieved.

2. Vaginitis: the vagina is bright red, the surface is visible with white netting. In severe cases, it can invade the cervix. It may have green or bloody secretions. Although the condition can be relieved periodically, the vaginal mucosa shrinks and the fragility increases during rest. Frequent sexual intercourse or bleeding after sexual intercourse, the symptoms of vulvitis and vaginitis are not necessarily parallel.

3. Gingivitis: The upper jaw gum is a good site, which can be followed by vulvitis and vaginitis at intervals of 2 to 9 years. The surface of the gums is diffuse flushing, erosion, easy bleeding, and the white mesh is visible on the edge of the erosion. White lines are also visible on the strips, normal gingival mucosa and buccal mucosa, and no adhesion occurs.

According to the clinical manifestations of erosive vulvitis, vaginitis and gingivitis characteristics, but the damage of the three sites does not necessarily occur at the same time, may only occur in 1 or 2 sites, according to medical history, clinical manifestations and pathological biopsy results Diagnosing clinical symptoms that support the diagnosis of lichen planus include: a narrow white reticular border around the lesion that is corroded by the vulva, and a regular examination of the mucosa for oral lichen planus in the non-erosive lichen planus of the skin mucosa. Surface lesions; biopsies taken from white reticular borders often show typical lichen planus-like tissue structures; biopsies taken from the surface of erosion centers often show non-specific inflammatory responses.

Differential diagnosis

1. Idiopathic desquamative vaginitis: non-infectious, idiopathic, erosive lesions, often vaginal adhesions and stenosis.

2. Idiopathic erosive vaginitis: also known as Gariner erythema hyperplasia, plasma cell vulvitis, no oral lesions.

3. erythroplasic rorm of vulva lichen sclerosis: manifested as inflammatory, erosive vulvitis, vulvar atrophy, may be associated with lichen planus or moss hardening.

4. desquamate erosive gingivitis, such as the occurrence of layered exfoliation around the gums of patients, often suggest that chronic exfoliating gingivitis may be derived from benign pemphigoid, should be differentiated from early scar-like pemphigoid .

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