Verrucous dyskeratosis

Introduction to sinus keratosis Sickle keratosis is a rare skin benign tumor, also known as isolated follicular keratosis, whose histological features are local acanthosis and poor keratosis. According to the organization of the disease, it can be divided into three types: cup, sac, nodular. More than one of the above symptoms may also occur in the same patient. basic knowledge The proportion of illness: 0.003% Susceptible people: no specific population Mode of infection: non-infectious Complications: sepsis

Causes of sickle keratosis

(1) Causes of the disease

The cause is still unknown. Some people think that this disease is a single-type Darier disease.

(two) pathogenesis

Oral damage can be secondary to irritation and trauma. Tobacco and other chemical carcinogens may be associated with oral damage. Skin damage occurs in exposed areas and may be associated with long-term UV exposure. Some people suspect that the disease is like pemphigus. There may be circulating antibodies that cause acanthosis to resolve.

Prevention of sickle keratosis

Early detection, early diagnosis, and early treatment are important for indirect prevention of this disease. For patients with existing skin infections, they can be rubbed with iodophor or rubbed with Baidubang.

Complications of sigmoid keratosis Complications sepsis

Due to poor keratinization of the skin, destruction of skin integrity, and often accompanied by itchy skin, it may cause skin bacterial infection or fungal infection due to scratching, usually secondary to low body constitution, long-term use of immunosuppressants and nails, etc. Patients with fungal infections, such as concurrent bacterial infections, may have symptoms such as fever, swelling of the skin, ulceration, and purulent secretion. Severe cases can lead to sepsis.

Symptoms of sigmoid keratosis common symptoms pruritus keratinized papule nodules

Skin lesions mainly occur in the face, head, neck and armpits, occasionally in the mouth, starting from 40 to 50 years old, more male than female, the skin lesions are flesh-colored to brown pimples, the edges are smooth and curled, and the center is hyperkeratotic In the damage, the smelly cheese-like substance can be discharged. The skin lesions are usually single-shot. There are also reports of multiple infections, which may cause itching and bleeding, but most of them have no subjective symptoms, clinical diagnosis is difficult, and there is no report of malignant transformation. Oral damage is rare, similar to skin damage, damage is usually not painful, occurs on the keratinized mucosa formed by trauma, small papules and nodules, the center is crater-like, can be papillary-like appearance, the color is flesh-colored white.

Examination of sickle keratosis

Histopathology: There is a large flask-like depression in the center of the lesion, and the channel is connected to the surface. The channel is filled with keratin substances. The upper part of the large depression contains many cells with acantholytic and dyskeratosis. Fluff, the latter being a significantly longer dermal papilla that is covered with only one layer of basal cells and protrudes upward from the bottom of the cup-shaped depression.

In the upward growth of the villus, there is an irregular downward-growth epidermis, which is often a double-layered basal cell, separated by a narrow crack. There are a few keratinized acantholytic cells in the crack, which are lined at the entrance of the depression. Typical round somatic cells are common in channels that thicken the granular layer.

Diagnosis and differentiation of sickle keratosis

According to the clinical manifestations of lesion characteristics and histopathology can be diagnosed.

The disease should be differentiated from other acantholytic diseases such as Darier disease, familial benign pemphigus and proliferative pemphigus, except for the clinical symptoms, the three are not in the form of flasks seen in the dysplasia Depression, in addition, the acantholytic layer is lighter than familial benign pemphigus and proliferative pemphigus, proliferative pemphigus can be seen in a large number of eosinophil infiltration, direct immunofluorescence can be identified by epidermal reticular fluorescence, Darier disease The round body and grain formation are much more pronounced than the sickle keratosis.

The disease should also be differentiated from papillary sweat gland cystadenoma, the latter is still eroded, showing a large number of plasma cells, no horny plug.

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