Hormone-dependent dermatitis

Introduction to hormone-dependent dermatitis Corticosteroid-dependent dermatitis (referred to as hormone-dependent dermatitis) is a dermatitis caused by long-term repeated inappropriate topical hormones. In recent years, the incidence has been increasing year by year, and it is stubborn and difficult to cure. It has become the focus of medical experts. basic knowledge Sickness ratio: 0.001%-0.002% Susceptible people: no specific population Mode of infection: non-infectious Complications: Diabetes Hypertension Osteoporosis Obesity Cardiovascular disease

Hormone-dependent dermatitis etiology

Indications selection error (10%):

Corticosteroids have anti-allergic effects that suppress the immune response. After external use, they can alleviate congestion and edema, and the degree of itching and the inflammatory reaction of some skin lesions are temporarily alleviated and subsided. People are often confused by this illusion, plus advertising. Misleading publicity, many people lack understanding of the scope of hormone application and adverse reactions and long-term abuse, leading to adverse consequences, a few people also use these drugs instead of skin cream to wipe the face, long-term use on normal face, feel good when used For a long time, it will produce dependence dermatitis; some also misunderstand the anti-inflammatory effect of corticosteroids as anti-inflammatory and antibacterial effects of antibiotics, and long-term repeated abuse, such as common skin diseases, acne (puberty acne), seborrheic Sexual dermatitis, femoral hernia, impetigo and other bacteria, fungal infectious skin diseases, eczema, dermatitis and other allergic skin diseases, especially in the face, genital skin diseases, long-term use of strong hormone preparations, because of these parts It is easy to absorb corticosteroids on the skin, and side effects are relatively easy to occur; it is easy to cause skin bruising Shrinking, thinning, telangiectasia, pigmentation spots, skin wrinkle and aging, especially in infants and young children, delicate skin, not suitable for long-term use in large areas, such as absorption through the skin, can also cause adrenal function inhibition, causing serious maladjustment as a result of.

Improper selection of drugs (25%):

The potent preparation of corticosteroids is most likely to cause side effects such as skin atrophy, but due to the randomness of the users, such drugs have been abused. Experiments have shown that in Pikangwang cream, dermatitis cream, skin relaxing cream, freckle cream, Among the 7 types of drugs, such as beclomethasone cream, compound Kangnaile cream and skin cream, the per capita dosage of Pi Kangwang cream is the lowest, but the proportion of side effects is as high as 60.4%. One of the reasons is that the drug Contains the most potent preparation, clobetasol, and this feature is not known to the user.

The medication takes too long (5%):

Short-term topical corticosteroids can cause epidermal atrophy and inhibit the synthesis of dermal collagen. Long-term large-scale external use can cause systemic side effects. Experiments have shown that long-term use of drugs leads to weakened skin barrier function, increased absorption of drugs, and formation of malignancy. Circulation, eventually worsening the condition, such as a male seborrheic dermatitis, the rotation of a variety of corticosteroids rubbing, for 14 consecutive years, in addition to facial diversity lesions and Cushing syndrome performance, also developed drug-induced diabetes There is a female chloasma patient who rubs with Pi Kangwang for 3 consecutive days. Not only does the facial skin have side effects, but also the drug-induced Cushing syndrome occurs. It can be seen that even if the corticosteroids are rubbed outside a small area, if the time is too long , can also lead to systemic side effects.

Confusion in the beauty market and abuse of beauty cosmetics (35%):

In the past ten years, with the rapid development of the beauty industry and the fierce competition of beauty salons, some beauty salons have tried to attract consumers, incorporate hormones into skin rejuvenation, and whiten cosmetics have deceived consumers, making many people eager for beauty and skin care. Consumers, after long-term application of their so-called "special skin rejuvenation, whitening cosmetics", rely on hormone-dependent dermatitis.

Hormone-dependent dermatitis prevention

1. Strict management. Relevant personnel of pharmacists such as hospitals and pharmacies must strictly control the distribution of hormone-containing products, and review the prescriptions of hormone-containing products prescribed by doctors;

2, strict supervision, the relevant state departments need to be more scientific and complete classification and management of drugs, all hormone-containing drugs should be included in the management of prescription drugs, with the doctor's prescription before they can purchase drugs;

3, strict indications, the doctor should have the basic knowledge of hormone-dependent dermatitis, and give sufficient instructions when the patient visits, let the patient know and use the doctor's advice;

4. Severe punishment. For producers who illegally add hormonal components to non-pharmaceuticals and pharmaceuticals, dealers should impose more severe penalties and sanctions according to the circumstances to increase illegal costs;

5. Science education, all relevant units and professionals should widely inform the general population about the characteristics and side effects of hormone-containing products, so that patients have the basic knowledge of preventing hormone dependence;

6, rational consumption, can not pursue quick-acting, magical effects and abuse of hormones.

Hormone-dependent dermatitis complications Complications diabetes hypertensive osteoporosis obesity cardiovascular disease

Hormones can be absorbed into the blood circulation by percutaneous absorption, causing iatrogenic diabetes, hypertension, osteoporosis, liver and kidney damage, obesity, menstrual disorders, and exacerbations of cardiovascular disease in the elderly.

Hormone-dependent dermatitis symptoms Common symptoms Itching photoallergic papules Skin brown sugar hormone dependence withdrawal response

(1) Externally used high-efficiency corticosteroids for more than 3 weeks, skin erythema, papules, dry desquamation, atrophy, atrophic lines, telangiectasia, purpura, hemorrhoids, hyperpigmentation, rosacea dermatitis, perioral dermatitis , photoallergic, hairy, unrecognizable sputum, secondary symptoms such as ichthyosis-like changes.

(2) After applying the above-mentioned hormone drugs, the primary disease condition can be rapidly improved; once the drug is stopped, within 1-2 days, the skin of the drug site has significant erythema, papules, cleft palate, desquamation, small abscesses, itching and tenderness. When the drug is used again, the above symptoms and signs will quickly decrease. If it is stopped again, the symptoms of dermatitis will re-emerge rapidly and gradually increase, and the dependence on hormones is more obvious, especially in the face and genital area. .

(3) There is a local conscious itch or burning sensation.

Hormone-dependent dermatitis examination

According to the long-term topical hormone or hormone-containing cosmetics, the history and unique skin lesions can be diagnosed without excessive examination.

Diagnosis and differentiation of hormone-dependent dermatitis

According to the long-term topical hormone or hormone-containing cosmetics, the history and unique skin lesions can be diagnosed, but it needs to be differentiated from facial paralysis, hemorrhoids, rosacea, seborrheic dermatitis, frostbite-like lupus, and facial disseminated miliary lupus.

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