Acquired Circulatory Anticoagulant Hypertension Syndrome

Introduction to acquired circulatory anticoagulant syndrome Acquired circulatory anticoagulant substance syndrome refers to the increase of circulating anticoagulant substances in the blood (including excessive heparin-like anticoagulant substances, excessive anticoagulant drugs, lupus anticoagulant substances, etc.) Group disease. Clinical manifestations vary with the primary disease. Bleeding performance and anticoagulant substances depend on the degree of inactivation of coagulation factors. Severe anti-Factor VIII antibodies can reduce Factor VIII activity to zero, and typical hemorrhagic symptoms of hemophilia can die from severe bleeding. basic knowledge The proportion of illness: 0.005% Susceptible people: no special people Mode of infection: non-infectious complication:

Acquired circulatory anticoagulant substance syndrome

Multiple fresh blood (30%):

Some patients with hemophilia repeatedly lose fresh plasma, whole blood or anti-hemophilia globulin, and produce antibodies to factor VIII, but the products are not parallel with the frequency, frequency and type of blood transfusion, and may be family-specific or Human leukocyte antigen (HLA) is associated with an incidence of 5% to 21%;

Immune response disease (30%):

Accompanied by immune response or such as systemic lupus erythematosus, rheumatoid arthritis, ulcerative colitis, bronchial asthma, penicillin reaction, etc., healthy women are produced in late pregnancy or postpartum 1 to several months, factor VIII inhibitor is an antibody Most of them belong to IgG, and a small number of IgG and IgM are mixed. Usually, light chain type is common, and and light chain mixed type are also common.

Other factors (20%):

The iatrogenic anticoagulant is mainly heparin and dicoumarin anticoagulant.

Acquired circulatory anticoagulant substance syndrome prevention

First of all, you need to develop good living habits. It is recommended to drink a large cup of warm boiled water on an empty stomach in the morning, supplement the water from the breath during the nighttime sleep, dilute the blood from the skin, and quit smoking, stop drinking, eat light, do not blindly Intravenous infusion therapy, because intravenous medication may have some side effects, be sure to choose the best treatment under the guidance of a doctor.

Acquired circulatory complications of anticoagulant syndrome Complication

The disease also causes bloody symptoms and can die from severe bleeding.

Acquired circulatory anticoagulant syndrome syndrome symptoms common symptoms repeated hemorrhage bleeding tendency

The clinical manifestations vary with the primary disease. The hemorrhagic manifestations and anticoagulant substances depend on the degree of inactivation of coagulation factors. In severe cases, anti-Factor VIII antibodies can reduce the activity of factor VIII to zero. The typical hemorrhagic symptoms of hemophilia can be severe. Hemorrhagic death, factor V and factor VIII clinical bleeding symptoms are mild, but there may be hemorrhage after trauma or surgery; systemic lupus erythematosus inhibitors have no clinically significant bleeding, but bleeding complications can occur during surgery.

Examination of acquired circulatory anticoagulant syndrome

After adding a small amount of patient plasma to normal human blood or calcium-depleted plasma, the clotting time, partial thromboplastin time and prolonged calcium time prolonged, suggesting the presence of anticoagulant substances. The difference between this disease and coagulation factor deficiency lies in The latter can be corrected by adding a small amount of normal human plasma to the plasma, while the anticoagulant can not be corrected. The factor VIII deficiency can measure the anticoagulant titer and the antibody neutralization test, and the heparin-like anticoagulant can be used as the thrombin time. Toluidine blue correction test confirmed.

Diagnosis and differentiation of acquired circulatory anticoagulant syndrome

diagnosis

Diagnosis can be based on medical history, clinical symptoms, and laboratory tests.

Differential diagnosis

The disease needs to be differentiated from the syndrome of increased anticoagulant substances caused by endogenous inhibitory substances of blood coagulation factors.

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