Pharyngeal Schwannoma

Introduction to pharyngeal nerve sheath tumor Pharyngeal schwannomas originate in the peripheral cranial nerve, sympathetic nerve and its branch tumors, which occur in the posterior pharyngeal wall and lateral wall. Histological nerve sheath tumors can be divided into neurofibromas and schwannomas (snow Wang's disease). The disease is an autosomal dominant genetic disease. The disease is slow, when it is small, it can be asymptomatic, accidentally found or has a foreign body sensation, obvious discomfort, followed by dysphagia and voice changes, larger tumors may have difficulty breathing, compression nerves may have pain, may be located in the nasopharyngeal Reduced hearing. basic knowledge The proportion of illness: 0.001% Susceptible people: no special people Mode of infection: non-infectious Complications: gastrointestinal bleeding

Cause of pharyngeal nerve sheath tumor

Mainly autosomal dominant genetic disease. The pathogenic gene of NF1 is located on the autosome 17q11.2. In the case of the disease, this chromosomal locus is deleted, so that the patient cannot produce the corresponding protein-neurofibroma protein. Neurofibromatosis protein is a tumor suppressor that slows cell proliferation by accelerating the activity of reducing the proto-oncogene p21-ras, which plays a major role in the intracellular mitosis signal transduction system.

Pharyngeal nerve sheath tumor prevention

There is no effective preventive measure for this disease, and the dietary structure based on plant food is selected. Usually, vegetables, fruits, beans and rough-processed staple foods are often eaten. These foods not only help prevent cardiovascular and cerebrovascular diseases, but also help prevent cancer. .

Pharyngeal nerve sheath tumor complications Complications, gastrointestinal bleeding

There are swallowing disorders and voice changes, larger tumors may have difficulty breathing, compression nerves may have pain, and those located in the nasopharyngeal may have hearing loss. Bone damage: A small number of patients develop skeletal dysplasia at birth, or abnormalities caused by compression of bone during tumor growth. Visceral damage: Neurofibromas growing in the chest, mediastinum, abdominal cavity or pelvic cavity can cause visceral symptoms, which can cause gastrointestinal bleeding or obstruction, and can also cause endocrine abnormalities.

Symptoms of pharyngeal schwannomas Common symptoms Ankle perforation Pharyngeal foreign body sensation dysphagia Hearing loss Dysphagia Throat pain

The disease grows slowly, can be asymptomatic when small, accidentally found or has a foreign body sensation, obvious discomfort, followed by dysphagia and speech changes, larger tumors may have difficulty breathing, compression nerves may have pain, may be located in the nasopharyngeal Reduced hearing. The posterior pharyngeal wall can be seen in the examination, the side wall has a rounded bulge, and the surface has a mucous membrane; the tumor is larger than the soft sacral bulge, or exceeds the midline of the pharynx, the zygomatic arch, the tonsil has a shift, etc., palpation can reach a hard mass, sometimes It is consistent with the direction of cranial nerve walking and has signs of nerve involvement.

Examination of pharyngeal nerve sheath tumor

Postoperative biopsy: histology can be divided into neurofibromatosis and schwannomas (Schwann's disease), neurofibromatosis is mainly composed of Schwann cells, but its interstitial cells are composed of collagen fibers and mucus Ingredients, the tumor is effective in obvious film, it is difficult to find its originating nerve, the texture is hard, the cut surface is light gray, the tumor cells are fusiform twisted under the microscope, the fusiform shape is arranged in a thin bundle, and there are a lot of collagen fibers between cells. The glassy and mucoid-like matrix is a staining reaction of mucopolysaccharide, which originates from the Schwann cells of nerve fibers and has a capsule composed of the outer membrane. The originating nerve can be attached to the outer membrane or under the membrane. However, the tumor is soft or hard, and may have a fluctuating sensation. It is yellowish-brown or gray-red. There is a bleeding point. The microscopic cells are arranged in the same nuclear-nuclear manner, tightly fenced, or loosely arranged. It is reticular and has a watery matrix.

Diagnosis and diagnosis of pharyngeal nerve sheath tumor

Diagnosis can be based on medical history, clinical symptoms, and laboratory tests.

Should pay attention to the differentiation of neurofibromatosis, benign mixed tumor, teratoma and malignant tumor, disease progression and pathological examination can be identified.

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