Cancerous neuromyopathy

Introduction to cancerous neuromuscular disease Cancerous neuromuscular disease refers to a disease of cancerous neuromuscular disease and dysfunction caused by non-tumor direct invasion of a patient with malignant tumor, that is, it has nothing to do with the cancer infiltration, but occurs before and after the symptoms of the primary tumor of the cancer. Unique neurological, mental and myopathy lesions. The pathogenesis has not yet been fully elucidated, and its pathogenesis is not related to cancer toxins, infections, metabolic disorders and dystrophies, and may be related to immune responses caused by autoimmunity or cancer. basic knowledge Sickness ratio: 0.0001% Susceptible people: no specific population Mode of infection: non-infectious Complications:

Cause of cancerous neuromuscular disease

The pathogenesis has not been fully elucidated, and its pathogenesis is not related to cancer toxins, infections, metabolic disorders and dystrophies. It may be related to the immune response caused by autoimmunity or cancer. There is no fixed relationship between the course of neuromuscular disease and cancer. The severity of neuromuscular disease is not parallel with the size and growth rate of cancer. Some symptoms may appear before the onset of cancer symptoms, and even seek medical treatment based on neuromuscular symptoms. Common in lung cancer, followed by breast cancer, other digestive tract cancer, cervical cancer, rectal cancer, prostate cancer, lymphoma, multiple myeloma and so on.

Cancer neuromyopathy prevention

The pathogenesis of this disease has not yet been fully elucidated. There is no special measure for prevention. Early detection and early treatment are the key.

Complications of cancerous neuromuscular disease Complications

1. If it is a brain lesion, it can lead to mental retardation.

2. Muscle atrophy, weakness, and eventually lead to paralysis.

3. Patients with spinal cord disease, severe cases lead to death.

Symptoms of cancerous neuromuscular disease Common symptoms Limb numbness deep sensory disorder Involuntary movement Facial muscle weakness Sensory disturbance Ataxia

First, peripheral neuropathy

(1) Sensory peripheral neuropathy, mostly subacute or late onset, mainly manifested by different degrees of numbness, pain or abnormal sensation at the distal end of the extremities, gradually progressing, and developing to the proximal end, in the form of gloves or short socks. Shallow, deep sensory disturbance, often accompanied by subacute small and cortical degeneration, normal or elevated protein in the cerebrospinal fluid.

(2) Sensory-sports type peripheral neuropathy, this type is more common in patients with lung cancer, and the onset is more urgent. The main manifestations are symmetrical muscle weakness in the distal extremities, muscle atrophy and sacral reflexes, and may be accompanied by lighter limbs. Feeling disorder, cerebrospinal fluid is more normal.

Second, muscle disease

(1) Cancer myasthenia gravis syndrome, which is common in small cell undifferentiated lung cancer, mainly manifested as limb muscle weakness, may also involve the muscles of the lips and throat, pronunciation and expression, and muscle strength after active exercise. Increased, most of the lack of response to neostigmine, electromyogram repeat electrical stimulation without amplitude decline phenomenon, which is different from myasthenia gravis.

(2) Myasthenia gravis, more common in thymoma or thymic cancer, the symptoms are the same as myasthenia gravis.

Third, spinal cord disease

Clinically, it can be characterized by progressive spinal muscular atrophy, amyotrophic lateral sclerosis, subacute necrotizing spinal cord disease or transverse myelitis. The disease progresses rapidly and can lead to death.

Fourth, encephalopathy

(1) Subacute cerebellar cortical degeneration, which is acute or subacute onset, mainly manifested as cerebellar ataxia, and may also have nystagmus and mental disorders.

(2) Chronic organic psychosis, mostly slow, manifested as mental retardation, memory impairment, depression or euphoria, occasionally Korsakov syndrome, may also have episodes of seizures, paralysis, aphasia and involuntary movements.

(3) marginal encephalitis, only in the pathological examination of the limbic system of the hippocampus, banded back, frontal lobe and other brain-like changes, but clinically no "encephalitis"-like performance.

Examination of cancerous neuromuscular disease

Clinical physical examination: varying degrees of numbness, pain, or abnormal sensation at the distal end of the extremities. Gradually proceed and develop to the near end, with a shallow, deep sensory barrier in gloves or short socks. Often accompanied by subacute small and cortical degeneration.

Laboratory examination: Lumbar puncture cerebrospinal fluid examination showed normal or elevated protein in the cerebrospinal fluid. Blood routine examination, white blood cells often increase. Electromyography, erythrocyte sedimentation, liver function, kidney function examination, etc.

Diagnosis and diagnosis of cancerous neuromuscular disease

diagnosis

Diagnosis can be based on medical history, clinical symptoms, and laboratory findings.

Differential diagnosis

In differential diagnosis, cancerous peripheral neuropathy is differentiated from peripheral neuritis caused by various causes and peripheral neuropathy caused by anticancer drugs; muscle changes should be associated with myasthenia gravis, non-cancerous polymyositis and dermatomyositis Identification; spinal cord lesions should be differentiated from motor neuron disease, acute transverse myelitis; and other encephalopathy.

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