cerebrospinal fluid C-reactive protein

CRP in cerebrospinal fluid is mainly from plasma. The concentration of CRP in CSF depends on the concentration of CRP in serum and the permeability to blood-brain barrier, which is an important diagnostic indicator of bacterial meningitis. Basic Information Specialist classification: neurological examination classification: cerebrospinal fluid examination Applicable gender: whether men and women apply fasting: fasting Tips: Patients with a history of rheumatism should seek medical advice. Normal value Adult 0.42 ~ 5.2μg / ml; Newborns 0.1 ~ 0.6μg / ml; Children 0.15 ~ 1.6μg / ml; School age children 0.17 ~ 2.2μg / ml; Pregnant women can reach 4.4 ~ 46.8μg / ml. Clinical significance Abnormal result (1) In purulent or tuberculous meningitis, the content of CRP in cerebrospinal fluid and serum is quite high. (2) In the case of serous meningitis or encephalitis, CRP is sometimes only seen in the cerebrospinal fluid. (3) Patients with central nervous system inflammation increase in the acute phase and disappear in the recovery phase. Need to check the crowd Suspected of purulent or tuberculous meningitis symptoms. High results may be diseases: pediatric haemophilic influenza, meningitis, tuberculous meningitis, suppurative meningitis Preparation before inspection: 1. Rheumatoid factor (RF) interferes with this test and produces false positive results. Therefore, patients with rheumatoid arthritis should use this test to determine whether their disease is active. They should pre-treat the serum to destroy the RF. Requirements for inspection: 1. Serum samples should not be diluted with normal saline. 2, latex reagents can not be frozen, should be stored at 2 ~ 8 ° C, valid for one year. Shake well before use. 3, room temperature <20 ° C, after adding latex reagent, extend the shaking time for 2 min. Inspection process The detection methods of CRP can be roughly divided into three types: immunoprecipitation, immunoturbidimetry and labeled immunoassay. CRP helps to reveal inflammation and tissue damage early in the clinic and is currently the target for the diagnosis of various diseases. Clinically, CRP has been applied to the diagnosis and monitoring of autoimmune and infectious diseases. It is also a predictor of future events in patients with acute coronary syndrome (ACS), stability and unstable angina, and stent placement. However, the traditional laboratory of CRP has been insufficient to predict the risk of cardiovascular events due to lack of sensitivity. Not suitable for the crowd 1. If there is obvious papilledema or cerebral palsy, contraindications are contraindicated. 2. Patients who are in shock, exhaustion or endangered state and local skin inflammation, and lesions in the posterior cranial fossa are contraindicated. 3. Because rheumatoid factor (RF) interferes with this test, it produces false positive results. Therefore, patients with rheumatoid arthritis should use this test to judge whether their disease is active. They should pre-treat the tested serum to destroy RF, so there is a history of rheumatism. Patients should seek medical advice. Adverse reactions and risks If the patient has symptoms such as breathing, pulse, or abnormal color during puncture, stop the operation immediately and deal with it accordingly.

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