cortisone water test

If a normal person drinks plenty of water in a short period of time, due to the large amount of water absorbed, the blood is diluted, and the hypothalamic-pituitary secretion of antidiuretic hormone is reduced, so the amount of urine is greatly increased, which is called "water diuretic effect." In addition to the blood circulation and kidney, the water-containing urine function is mainly involved in the regulation of glucocorticoids secreted by vasopressin and adrenal cortex. When adrenal insufficiency, glomerular filtration rate decreased, hypothalamic-pituitary secretion increased diuretic hormone, there was a significant diuretic delay, and the highest monthly urine output (<10ml). This water diuretic reaction Defects can be corrected by glucocorticoids. Basic Information Specialist classification: urinary examination classification: endocrine examination Applicable gender: whether men and women apply fasting: fasting Tips: If the subject has heart failure, cirrhosis, kidney disease and hypothyroidism, this test is often not normal. Normal value The highest urine output is >10ml/min (>0.17ml/s). Clinical significance Abnormal results: After a normal person drinks plenty of water on an empty stomach, the urine volume increases in about 20 to 30 minutes, and reaches the highest peak within 2 hours. The total urination is close to or exceeds the amount of drinking water. Therefore, the normal human water diuretic test, such as its maximum urine output per minute exceeds 10 ml, the cortisone water test did not change. However, when the anterior pituitary dysfunction or adrenal insufficiency declines, due to the occurrence of water diuretic disorder, the amount of water consumed cannot be drained within 2 hours or even 5 hours. At this time, the cortisone water test, the urine volume is greatly increased, and the maximum urine output per minute can be restored or nearly normal. Need to check the crowd: patients with dysuria, less urination, consider patients with glandular dysfunction. Precautions Forbidden before examination: suspected adrenal insufficiency should be measured first. Requirements for inspection: Collect urine regularly and inform the caregiver in time. If the subject has heart failure, cirrhosis, kidney disease, and hypothyroidism, this test is often not normal. Inspection process The method is: drinking water is prohibited after dinner before the test. On the morning of the test day, on an empty stomach in the morning, after urinating and discarding, drink 1000ml (or 20mg/kg) in 20min. Thereafter, urine was collected once every 20 minutes (calculating the amount of urine per second or per minute) for a total of 8 times for 160 minutes. On the second day, the first day of the test was repeated under the same conditions, but 75 mg of cortisone was orally administered 4 hours before drinking. If the maximum daily urine output per minute has exceeded 10 ml, the second day test may be considered. Not suitable for the crowd Those with low blood sodium. Adverse reactions and risks Generally not.

The material in this site is intended to be of general informational use and is not intended to constitute medical advice, probable diagnosis, or recommended treatments.