Bone marrow imaging

Bone marrow tissue is divided into two major types of red pulp with hematopoietic function and the main component is the yellow pulp of fat cells. Normal adult red pulp is mainly distributed in the proximal end of the trunk bone, skull, femur and tibia. All the bone marrow cavity of the newborn is filled with red pulp. As the age increases, the peripheral red pulp gradually shrinks from far and near. Under the influence of pathological factors (hypoxia, anemia, etc.), the process of transforming red pulp into yellow pulp can be reversed. At present, the commonly used detection techniques in clinical practice can not show the distribution and activity of red pulp. Radionuclide bone marrow imaging can show the total volume, distribution range and functional status of local bone marrow, and provide accurate localization for bone marrow biopsy. Basic Information Specialist Category: Cardiovascular Examination Category: Radionuclide Applicable gender: whether men and women apply fasting: not fasting Tips: Don't have an empty stomach. Drink 500-1000ml of water within 2 hours after injection of the imaging agent. Normal value The healthy adult center has clear bone marrow development; the lower thoracic vertebrae and the upper lumbar vertebrae cannot be clearly displayed due to the strong radioactivity of the liver and spleen; the peripheral bone marrow is only developed on the upper third of the tibia and femur. Functional bone marrow development distribution has significant physiological differences with age. The bone marrow and peripheral bone marrow of the Healthy Children's Center were clearly developed; after 10-12 years of age, except for the development of the epiphysis, the remaining images were basically the same as those of adults. Clinical significance Abnormal result 1. Aplastic anemia (AA) systemic bone marrow imaging is generally sparse, bone marrow activity <2; central bone marrow suppression, peripheral bone marrow expansion; normal bone marrow imaging, activity level 2. 2. Leukemia (leukocythemia) auxiliary diagnosis center bone marrow suppression, peripheral bone marrow expansion; splenomegaly; bone marrow fibrosis. 3. Multiple myeloma (multiple myeloma) myeloma is a malignant tumor caused by abnormal proliferation of bone marrow plasma cells; single or multiple defect areas of central bone marrow; peripheral bone marrow expansion; sensitivity is higher than bone imaging. 4. Bone marrow embolization (bonemarrowembolism) focal radioactive defect area, the surrounding active red bone marrow area is radioactive concentration; sometimes accompanied by peripheral bone marrow expansion. 5. Avascular necrosis of the femoral head Avascular necrosis of the femoral head first affects the bone marrow, and early X-ray examination is mostly negative. Bone marrow imaging is significantly superior to radionuclide bone imaging; radioactive reduction or defect in the affected femoral head; clearer than bone imaging. 6. Bone marrow fibrosis center bone marrow is suppressed, peripheral bone marrow expansion; with the development of the disease, peripheral bone marrow is gradually suppressed. 7. The globulism center of the bone marrow is normal or hyperplasia; peripheral bone marrow expansion; the whole bone marrow imaging is very clear; advanced hematopoietic failure, splenomegaly. 8. Guide the bone marrow imaging results of the bone marrow puncture site to help guide the clinical selection of the most representative puncture and biopsy sites, which is conducive to improving the correctness of blood disease diagnosis. At the same time, the total amount of active bone marrow can be known to make up for the deficiency of puncture examination, which has practical value for interpreting the puncture result. People who need to be examined: patients with bone marrow disease can be examined. Precautions Taboo before inspection: no need for an empty stomach. Drink 500-1000ml of water within 2 hours after injection of the imaging agent. Requirements for examination: imaging should be performed about 3-4 hours after the injection of the imaging agent. The urine should be emptied before the examination, and urine should be prevented from contaminating any part of the body. Inspection process Intravenous imaging agent 15-20mCi→interval 20-30min→front and posterior whole body imaging→local imaging→ROI calculated the ratio of bone marrow to surrounding soft tissue radioactivity (quantitative analysis). Not suitable for the crowd Inappropriate people: generally no requirements. Adverse reactions and risks Nothing.

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