Abnormal prothrombin (APT)

In the absence of vitamin K, hepatocytes cannot synthesize normal vitamin K-dependent coagulation factors (II, VII, IX, X) and can only synthesize abnormal prothrombin without coagulation. In hepatocellular carcinoma, a large amount of APT is produced due to abnormalities in the synthesis of prothrombin precursors by cancer cells and insufficient carboxylation of prothrombin precursors. The APT assay is a marker that reflects hepatocellular carcinoma. Basic Information Specialist classification: growth and development examination classification: blood examination Applicable gender: whether men and women apply fasting: fasting Tips: Seniors and smokers should be regularly checked to prevent disease. Normal value Abnormal prothrombin <20 μg / L (20 ng / ml). Clinical significance Abnormal result 1. See vitamin K deficiency caused by various reasons, such as the use of dicoumarin anticoagulants, long-term use of antibiotics (especially cephalosporin antibiotics), neonatal natural hemorrhagic disease, infants and young children with idiopathic vitamin K deficiency Symptoms, severe liver disease and vitamin K malabsorption. 2. Primary liver cancer. 3. As a differential diagnosis of vitamin K-deficient bleeding and non-vitamin K deficiency bleeding such as DIC. People who need to be examined: Liver cancer patients should be examined to make liver cancer measurements and research. Older people and smokers should be regularly checked to prevent disease. High results may be diseases: abnormal precautions for platelet procoagulant activity Inappropriate people: Oral anticoagulants, bile acid deficiency, intestinal flora disorders, etc. will also increase APT, so these people are not suitable for detecting ATP. Taboo before inspection: taboo overeating, strenuous exercise, to save quiet state. Requirements for examination: serum test is taken, and serum is not contaminated. Inspection process ELISA is used to quantify APT content in human serum, plasma, cell culture supernatant or other related biological fluids. Not suitable for the crowd 1. Patients who have taken contraceptives, thyroid hormones, steroid hormones, etc., may affect the results of the examination and prohibit patients who have recently taken the drug history. 2, special diseases: patients with hematopoietic function to reduce disease, such as leukemia, various anemia, myelodysplastic syndrome, etc., unless the examination is essential, try to draw less blood. Adverse reactions and risks 1, subcutaneous hemorrhage: due to pressing time less than 5 minutes or blood draw technology is not enough, etc. can cause subcutaneous bleeding. 2, discomfort: the puncture site may appear pain, swelling, tenderness, subcutaneous ecchymosis visible to the naked eye. 3, dizzy or fainting: in the blood draw, due to emotional overstress, fear, reflex caused by vagus nerve excitement, blood pressure decreased, etc. caused by insufficient blood supply to the brain caused by fainting or dizziness. 4. Risk of infection: If you use an unclean needle, you may be at risk of infection.

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