Myoglobin

Myoglobin is a small molecule protein whose molecular result is similar to hemoglobin and has the function of transporting and storing oxygen in muscle cells. Human myocardium and skeletal muscle contain a large amount of myoglobin, which is rarely found in normal human blood, and is mainly metabolized and excreted by the kidney. When the myocardium or striated muscle is damaged, myoglobin is released into the blood, and the myoglobin in the serum can be significantly increased. Myoglobin is present in the muscle and is particularly abundant in the myocardium. Sperm whale myoglobin tertiary structure was elucidated in 1960 by Kendrew using X-ray diffraction, the world's first described protein tertiary junction. Since the tertiary structure is directly related to the biological function of the protein, and the analysis of the tertiary structure is very difficult, this work has been highly evaluated by the academic community. Basic Information Specialist classification: cardiovascular examination classification: blood examination Applicable gender: whether men and women apply fasting: not fasting Analysis results: Below normal: Generally it is normal. Normal value: Male: 19-92μg/L Female: 12-76μg/L Above normal: Common in acute myocardial infarction, acute muscle injury, muscular dystrophy and other diseases. negative: Positive: Tips: Strenuous exercise, intramuscular injection, muscle trauma, cardiac catheterization, etc. are prohibited before the examination, because this can increase myoglobin. Normal value Male: 19～92μg/L; Female: 12 ~ 76μg / L. Note Each laboratory should have different reference values ​​depending on the test method. Clinical significance Determination of serum myoglobin can be used as an indicator for early diagnosis of myocardial infarction. Abnormal result Increased in early acute myocardial infarction, acute muscle injury, muscular dystrophy, muscular atrophy, polymyositis, acute or chronic renal failure, severe congestive heart failure and long-term shock. It can be increased 1.5h after myocardial infarction, but it will return to normal within 1~2d. Increased blood and urine myoglobin are found in acute myocardial infarction, angina pectoris, cardiogenic shock, cardiomyopathy, muscle disease (progressive muscular dystrophy, polymyositis, myasthenia gravis). 1, elevated blood in the thyroid function, high aldosteronism, renal insufficiency, malignant hyperthermia and after strenuous exercise. 2, elevated porphyria, hemoglobinuria, hematuria, etc. in the urine. People who need to be tested Heart disease, muscle disease patients. High results may be diseases: myocardial infarction, angina pectoris, myasthenia gravis, polymyositis, muscular dystrophy, myocarditis considerations Before the test: Strenuous exercise, intramuscular injection, muscle trauma, cardiac catheterization, etc. are prohibited, because this can increase myoglobin. Inspection process Immunological method: The antibody of the subject's hemoglobin is produced, and the blood of some subjects is taken and mixed with the prepared antibody to see the volume ratio of the precipitate to the total blood volume. Chemiluminescence method: The hemoglobin is marked with a chemical substance, and the ratio of the illuminant to the total blood volume is calculated by observing the record through a microscope. Not suitable for the crowd no. Adverse reactions and risks no.

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