serum fibronectin

Fn is an α2 glycoprotein consisting of two subunits, which can be divided into two forms, CFn and PFn. One of the main functions is as a transmitter of phagocytosis of macrophages and reticuloendothelial cells, promoting the retinal endothelial cells to fibrin, fibrinogen-fibrin complex, collagen fragments, damaged cell debris, bacteria And conditioning and removal of non-bacterial toxic substances. CFn is a matrix protein of connective tissue, which is distributed together with collagen fibers in the liver and elevated in liver fibrosis. Basic Information Specialist classification: Digestive examination classification: biochemical examination Applicable gender: whether men and women apply fasting: fasting Tips: After 8 pm on the day before the medical examination, you should fast, so as not to affect the next day's test. Normal value The one-way immunodiffusion method was 0.231±0.046 g/L (231±46 μg/ml). Clinical significance Reduced more common in organ failure, severe infection, severe hepatitis, decompensated cirrhosis, liver cancer metastasis, severe malnutrition. Low results may be diseases: liver cirrhosis, malignant malnutrition, alcoholic cirrhosis The reports on the reference values ​​vary greatly, and the influencing factors are: 1 method is different from reagent. 2 Fn binds to fibrin after blood coagulation, and the level of serum Fn is related to the speed of blood clot formation, temperature, environment, and the length of separation of serum and blood clot. There are experimental results indicating that serum or plasma is stored frozen, and should be melted in a 37 ° C water bath. If the room temperature is melted, the result is 20% lower than the original content. It is considered that the determination of Fn by plasma is superior to serum, and sodium citrate is used as an anticoagulant to keep plasma stable at low temperature storage. EDTA has the opposite effect. The Fn content in serum was determined by rapid immunization to be 37.05% lower than plasma. Inspection process Immediately after venous blood collection, the test method was determined by one-way immunodiffusion method. Not suitable for the crowd Inappropriate people: Generally there are no people who are not suitable. Adverse reactions and risks Discomfort: There may be pain, swelling, tenderness, and visible subcutaneous ecchymosis at the puncture site.

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