serum lecithin-cholesterol acyltransferase

LCAT is synthesized by the liver and functions as an enzyme in plasma. It catalyzes the transfer of lecithin-2-fatty acids in HDL to FC to form CE and lysophospholipids. Blood under the action of Apo above, LCAT can regulate both FC and CE. The LCAT selective substrate is HDL and has little effect on VLDL and LDL. Inherited hereditary and secondary LCAT deficiency, alcoholic hepatitis, abnormalities in HDL metabolism. Basic Information Specialist classification: Digestive examination classification: biochemical examination Applicable gender: whether men and women apply fasting: fasting Analysis results: Below normal: Reduced in acute hepatitis, severe hepatitis, liver cancer, cirrhosis, congenital lecithin-cholesterol acyltransferase deficiency, no β-lipoprotein (β-LP), obstructive jaundice, uremia, hypothyroidism, Myocardial infarction, Tangier disease, fisheye disease, hypocholesterolemia, malabsorption syndrome. Normal value: Serum lecithin-cholesterol acyltransferase: 5.19-7.05 mg/L Above normal: Increased in primary hyperlipidemia, fatty liver, early stage of cholestasis, nephrotic syndrome. negative: Positive: Warm reminder: blood cholesterol and lecithin concentration affect the determination results, so the experiment is compliant. Normal value 1. Radioimmunoassay (RIA) 5.19 to 7.05 mg/L. 2. Common matrix method (37 ° C) 262 ~ 502U / L. 3, the nuclear labeling itself matrix method 58 ~ 79U. Clinical significance 1. Reduced in acute hepatitis, severe hepatitis, liver cancer, cirrhosis, congenital lecithin-cholesterol acyltransferase deficiency, no β-lipoprotein (β-LP), obstructive jaundice, uremia, hypothyroidism Symptoms, myocardial infarction, Tangier disease, fisheye disease, hypocholesterolemia, malabsorption syndrome. 2, elevated in primary hyperlipidemia, fatty liver, early stage of cholestasis, nephrotic syndrome. Low results may be diseases: high fatty liver results may be diseases: phosphatidylcholine-cholesterol acyltransferase deficiency, nephrotic syndrome precautions The concentration of cholesterol and lecithin in the blood affects the measurement results, so a comparison is needed during the experiment. Inspection process Immediately after blood collection, the test method was determined by radioimmunoassay and radionuclide labeling itself. Not suitable for the crowd Special diseases: Patients with hematopoietic dysfunction, such as leukemia, various anemia, myelodysplastic syndrome, etc., unless the examination is essential, try to draw less blood. Adverse reactions and risks Discomfort: There may be pain, swelling, tenderness, and visible subcutaneous ecchymosis at the puncture site.

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