Sial creatinine

Urea, creatinine and uric acid in the plasma can enter the saliva through salivary gland cells, and the concentration in the saliva is related to the concentration in the plasma. Basic Information Specialist classification: oral examination classification: body fluid examination Applicable gender: whether men and women apply fasting: not fasting Analysis results: Below normal: Muscular atrophy, muscular dystrophy, hemodilution, and decreased infusion. Normal value: Salivary creatinine: 32.7-46.9μmol/L Above normal: GFR (glomerular filtration rate) is reduced: kidney disease, renal insufficiency, cardiac insufficiency, dehydration, etc. negative: Positive: Tips: Slight hemolysis can make creatinine determination results high, severe hemolysis can interfere with the results. Normal value 32.7 to 46.9 μmol/L. Clinical significance Urea, creatinine and uric acid in the plasma can enter the saliva through salivary gland cells, and the concentration in the saliva is related to the concentration in the plasma. Clinically, serum creatinine is one of the main methods used to understand renal function. 1. Raise: (1) GFR (glomerular filtration rate) reduction: kidney disease, renal insufficiency, cardiac insufficiency, dehydration, etc. (2) Concentration of blood (more associated with decreased GFR): dehydration, burns, cachexia, shock, etc. (3) Muscle mass: increase acromegaly, giant disease. (4) Other: hypothyroidism. 2, lower: Muscular atrophy, muscular dystrophy, hemodilution, and infusion. High results may be diseases: dehydration, acromegaly considerations 1. When measuring creatinine, the temperature of each tube should be reduced to room temperature, and then colorimetric, because the temperature increase can make the color of bitter acid solution deeper, but the standard and measurement are not consistent. 2. In order to ensure accurate and reliable test results, each test should include quality control serum, and the measured quality control value should fall within the allowable range. 3, WHO recommended creatinine picric acid colorimetric method OCV is ± 0.4%, RCV is ± 8%, China's recommended RCV is 8%. 4, such as homemade quality control serum, should pay special attention to the infection of hepatitis virus, and do a good job of disinfection. 5. If the sample sample is not tested on the day, it can be stored in the refrigerator for 3 days. If it is not tested for a long time, it can be stored at -20 °C. 6, slight hemolysis can make creatinine determination results are high, severe hemolysis can interfere with the results. 7. The protein-free blood filtrate used for the determination of creatinine is affected by the pH value. When the pH value is below 2, the recovery rate can reach 100%. 8. Bitter acid is poisonous. Do not swallow or touch the skin. If it is inadvertently contacted, rinse it with plenty of water in time. 9, the quality of picric acid should be high: to use AR above the level of reagents, such as picric acid reagent is not pure, can increase the absorbance of the blank tube and affect the measurement results. 10. Colorimetric should be completed within 15 minutes after color development. If the time is too long, the non-specific reaction of picric acid with other substances in the blood filtrate will affect the accuracy of the determination results. 11. Bitter acid is an explosive. To prevent accidents, it is best to use plastic bottles and add a little distilled water. Inspection process Creatinine reacts with basic picric acid to form an orange-red complex, which is determined by colorimetric at 510 nm. Detection was performed using a protein-free alkaline picric acid method. Not suitable for the crowd Those who do not have an indication for examination should not be examined. Adverse reactions and risks High creatinine may cause complications such as hyperkalemia, hyperuricemia, hyperlipidemia, hypoproteinemia, and metabolic acidosis. In patients with renal failure, creatinine is usually much higher than normal. When creatinine reaches 500, dialysis can be considered. Creatinine 500 is the critical point of dialysis, but not all patients require dialysis to reach 500 creatinine. Creatinine 500 is only suitable for most. Human reference value. Whether dialysis is needed depends on the specific physical condition of the patient. Dialysis of creatinine is very effective, but patients need to do dialysis on a regular basis. A slight relaxation of creatinine will quickly rise, even higher than the original, but long-term dialysis, the kidneys will not be used for a long time, to complete necrosis, with With the gradual decline of renal function, dialysis will become more and more frequent, and the last is uremia. Continued dialysis is only a way for kidney transplantation.

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