Hepatitis A Antibodies

Hepatitis A antibody is a specific antibody against hepatitis A. Hepatitis Avirus (HAV) is an icosahedral stereo-symmetric spherical particle with a diameter of 27-32 nm. It has no envelope and the core is single-stranded positive-stranded RNA. HAV is a hepatovirus or heparnavirus of the picornavirus family. HAV is mainly transmitted through the hand-to-mouth route, with an incubation period of 15 to 50 days, with an average of 28 days. The virus is often present in the patient's blood and feces 5 to 6 days before the patient's serum ALT rises. After 2 to 3 weeks of onset, the infectivity of serum and feces gradually disappears with the production of specific antibodies in serum. Laboratory testing of HAV allows for antibody testing. The most clinically used is the anti-HAV antibody by ELISA. Basic Information Specialist classification: Infectious disease examination and classification: liver function examination Applicable gender: whether men and women apply fasting: fasting Analysis results: Below normal: Normal value: no Above normal: negative: normal. Positive: Seen in the incubation period of hepatitis A and within a few days after onset. At this time, blood and feces are contagious. Feces are the main source of infection. The detection of hepatitis A virus can start from 1 to 2 weeks before onset, peak at the onset, and alanine aminotransferase (ALT) reaches the peak before detoxification. Tips: Anti-HAIgM positive can be diagnosed as hepatitis A. If low titer is detected, it should be retested every 2 weeks, but attention should be paid to false positive caused by rheumatoid factor. Normal value ELISA (1) Hepatitis A antibody immunoglobulin M (anti-HAVIgM) is negative. (2) Hepatitis A antibody immunoglobulin G (anti-HAV IgG) is negative. Clinical significance Abnormal results: This test is mainly used for the auxiliary diagnosis of hepatitis A. Positive: seen in the incubation period of hepatitis A and within a few days after onset. At this time, blood and feces are contagious. Feces are the main source of infection. The detection of hepatitis A virus can start from 1 to 2 weeks before onset, peak at the onset, and alanine aminotransferase (ALT) reaches the peak before detoxification. Generally, 50% of patients with acute hepatitis A can detect hepatitis A virus in the feces one week after hospitalization. The significance of the epidemiological investigation of hepatitis A virus is greater than clinical. Especially after the detection of hepatitis A in the child care institution, it is important to collect the same population of feces for early detection of the latent period and subclinical infection, so as to isolate the infection as soon as possible and cut off the source of infection, which is of great significance for controlling the epidemic of hepatitis A. Hepatitis A virus and its RNA detection can be used for food quarantine and tracking of infectious sources. For example, the quarantine of Hekoukou water source and shellfish food in the endemic area can determine the source of infection as early as possible. People who need to be tested: general malaise, nausea, vomiting and fever, fatigue, loss of appetite, abnormal liver function. Positive results may be diseases: hepatitis A precautions When testing: Anti-HAV-IgG appears later and lasts longer and is often negative at the beginning of the infection. It is commonly used in epidemiological investigations. Anti-HAIgM positive can be diagnosed as hepatitis A. If low titer is detected, it should be retested every 2 weeks, but attention should be paid to false positive caused by rheumatoid factor. Anti-HAIgG positive suggestive of HAV infection, but the double anti-HAIgG titer increased more than 4 times, also has diagnostic significance. Inspection process Anti-HAVIgM: Hepatitis A-specific antibody-(anti-HAVIgM) appears early, usually can be detected on the day of onset, peaking in the jaundice period, antibody titer decreases from January to February, most disappear from March to April . It is an important indicator for early diagnosis of hepatitis A. Commonly used methods are enzyme-linked immunosorbent assay (ELISA) and solid phase radioimmunoassay (SPRIA), which have high sensitivity and specificity. A routine item for the detection of patients with acute hepatitis. Rheumatoid factor-positive specimens may exhibit anti-HAVIgM false positives and should be noted. Anti-HAV IgG: When symptoms appear in patients with acute hepatitis A, anti-HAV IgG can be detected in the serum, the initial titer is low, and then gradually increases, peaking in March after the disease, maintaining a high level in 1 year, low level It can last for decades or even life in the blood. For example, the anti-HAV IgG titer of the double serum can increase the serum of the recovery period by more than 4 times, and the hepatitis A can be diagnosed. Often because of the late patient visit, the early serum is not harvested, and the antibody titer is not increased by 4 times. Therefore, this diagnostic method is basically not used clinically. Anti-HAV IgG is used to detect epidemiological investigations of population immunity. HAV-RNA utilizes cloned HAV cDNA fragments to make probes, and cDNA-RNA hybridization technology can be used to detect HAV-RNA in serum and feces of acute hepatitis A. Since the application of polymerase chain reaction (PCR) in clinic, A more sensitive method for detecting HAV-RNA. The reverse transcription-PCR (RT-PCR) method was used to convert HAV-RNA into cDNA using reverse transcriptase, followed by PCR detection. Positive for HAV-RNA, direct evidence of acute infection with HAV. Not suitable for the crowd There are no taboos. Adverse reactions and risks Generally no complications and harm.

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