Urinary free cortisol

Urinary free cortisol is filtered from the free cortisol in the blood by the glomerulus, so the amount is directly proportional to the truly bioactive free cortisol in the plasma. Determination of urinary free cortisol can effectively and correctly reflect the functional status of the adrenal cortex. The urine volume was taken for 24 hours, and 10 ml of glacial acetic acid was used as a preservative. Basic Information Specialist classification: urinary examination classification: urine / kidney function test Applicable gender: whether men and women apply fasting: not fasting Analysis results: Below normal: (1) Adrenal insufficiency, such as Addison, Simon, Sheehan syndrome, decreased plasma and urinary cortisol levels. (2) Long-term use of steroid hormones can inhibit ACTH secretion by negative feedback, and the adrenal cortex is inhibited or atrophied, and plasma and urinary cortisol levels are reduced. (3) Congenital adrenal hyperplasia, due to the lack of certain enzymes in the body such as C20-22 cleavage enzyme 3β-dehydrogenase, 17α-hydroxylase 11β hydroxylase and 18 hydroxylase, etc. Cortisol production is reduced. Normal value: Urinary free cortisol: 162.8-251.0nmol/24h Above normal: (1) Plasma and urinary cortisol increased significantly in cortisol, and the circadian rhythm of plasma disappeared. (2) Tumors of ectopically produced ACTH such as oat-type lung cancer, pancreas, thyroid, parathyroid gland, ovary, testis, large intestine, gallbladder, breast, and mediastinum have the function of secreting ACTH-like substances. Cortisol is synthesized in the adrenal cortex, and cortisol in plasma is significantly elevated. (3) anterior pituitary hyperfunction due to the secretion of hormones in the anterior pituitary, the target gland hyperplasia, plasma and urinary cortisol can be elevated. negative: Positive: Tips: Try to use fresh morning urine when doing this check. The urine that is randomly selected is preferably mid-stage urine. Menstrual women are not suitable for this examination. Normal value Adult 206.9 ± 44.1nmol / 24h urine (range 129.7 ~ 303.6) Clinical significance 1. Plasma and urinary cortisol increased significantly in cortisol, and the circadian rhythm of plasma disappeared. 2. Tumors of ectopically produced ACTH such as oat-type lung cancer, pancreas, thyroid, parathyroid gland, ovary, testis, large intestine, gallbladder, breast, and mediastinum have the function of secreting ACTH-like substances. Cortisol is synthesized in the adrenal cortex, and cortisol in plasma is significantly elevated. 3, anterior pituitary hyperfunction due to the secretion of hormones in the anterior pituitary, the target gland hyperplasia, plasma and urinary cortisol can be elevated. 4, adrenal insufficiency, such as Addison, Simon, Xi Han syndrome, plasma and urinary cortisol levels decreased. 5, long-term use of steroid hormones can inhibit ACTH secretion by negative feedback, so that the adrenal cortex is inhibited or atrophy, plasma and urinary cortisol levels are reduced. 6. Simple obesity, plasma and urinary cortisol levels are slightly higher or within the normal range. 7, congenital adrenal hyperplasia, due to the lack of certain enzymes such as C20-22 cleavage enzyme 3β-dehydrogenase, 17α-hydroxylase 11β hydroxylase and 18 hydroxylase to make cortisol synthesis disorders, and cortex Alcohol production is reduced. Low results may be diseases: pregnancy with chronic adrenal insufficiency, adrenal insufficiency, secondary adrenal insufficiency, adrenal insufficiency, high heart disease, possible disease: pediatric Cushing's syndrome, pituitary adenoma, Hypothalamic syndrome, Cushing syndrome considerations Note during inspection: Fresh morning urine should be used as much as possible during this examination. The urine that is randomly selected is preferably mid-stage urine. Not suitable for the crowd: menstrual women. Inspection process Inspection process: As with routine urine tests, use a clean, dry container with a disposable urine cup and urine test tube provided by the hospital. Take about 10 ml of urine and send it to the designated inspection window of the hospital, and then use the antibody method to detect it. Not suitable for the crowd Menstrual women. Adverse reactions and risks no.

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